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Transferrin stimulates iron absorption, exocytosis, and secretion in cultured intestinal cells
(1999)
The cellular mechanism by which basolateral transferrin (Tf) produces an increase in apical-to-basolateral Fe flux in Caco-2 cells was analyzed. After a pulse of 59Fe from the apical medium, three types of basolateral 59Fe ...
TRPC1 regulates calcium-activated chloride channels in salivary gland cells
(Wiley-liss, Div John Wiley & Sons Inc, 2015-11)
Calcium-activated chloride channel (CaCC) plays an important role in modulating epithelial secretion. It has been suggested that in salivary tissues, sustained fluid secretion is dependent on Ca2+ influx that activates ion ...
Angiotensin II has acute effects on TRPC6 channels in podocytes of freshly isolated glomeruli
(Nature Publishing Group, 2014-09)
A key role for podocytes in the pathogenesis of proteinuric renal diseases has been established. Angiotensin II causes depolarization and increased intracellular calcium concentration in podocytes; members of the cation ...
Major contribution of the 3/6/7 class of TRPC channels to myocardial ischemia/reperfusion and cellular hypoxia/reoxygenation injuries
(National Academy of Sciences, 2017)
Abstract: The injury phase after myocardial infarcts occurs during reperfusion and is a consequence of calcium release from internal stores combined with calcium entry, leading to cell death by apoptopic and necrotic ...
Ca2+ entry via TRPC1 is essential for cellular differentiation and modulates secretion via the SNARE complex
(Company of Biologists, 2019)
Abstract: Properties of adipocytes, including differentiation and adipokine secretion, are crucial factors in obesity-associated metabolic syndrome. Here, we provide evidence that Ca2+ influx in primary adipocytes, especially ...
Major contribution of the 3/6/7 class of TRPC channels to myocardial ischemia/reperfusion and cellular hypoxia/reoxygenation injuries
(National Academy of Sciences, 2017-05)
The injury phase after myocardial infarcts occurs during reperfusion and is a consequence of calcium release from internal stores combined with calcium entry, leading to cell death by apoptopic and necrotic processes. The ...
Mecanismos biofísicos do efeito excitatório de receptores metabotrópicos de glutamato do grupo I em neurônios do Locus Coeruleus
(Universidade Federal de Minas GeraisBrasilICB - DEPARTAMENTO DE FISIOLOGIA E BIOFÍSICAPrograma de Pós-Graduação em Ciências Biológicas - Fisiologia e FarmacologiaUFMG, 2022-08-10)
Metabotropic glutamate receptors (mGluR) mediate important roles in cellular excitability and plasticity in several regions of the nervous system. The activation of these receptors may involve ion channels and membrane ...