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Sitagliptin's effects on bone tissue and osseointegration in diabetic rats
(2019-06-01)
Objective: To investigate the effects of sitagliptin, a dipeptidyl peptidase 4 inhibitor used to treat type II diabetes, on bone tissue and on implant osseointegration in diabetic rats. Design: Thirty-two male rats were ...
Glucocorticoids mobilize macrophages by transcriptionally up-regulating the exopeptidase DPP4
(American Society of Biochemistry Molecular Biology, 2020)
Sitagliptin prevents the development of metabolic and hormonal disturbances, increased β-cell apoptosis and liver steatosis induced by a fructose-rich diet in normal rats
(Portland Press, 2011-01)
The aim of the present study was to test the effect of sitagliptin and exendin-4 upon metabolic alterations, β-cell mass decrease and hepatic steatosis induced by F (fructose) in rats. Normal adult male Wistar rats received ...
Desenvolvimento e validação de metodologia para avaliação de fosfato de sitagliptina
(Universidade Federal de Santa MariaBRFarmacologiaUFSMPrograma de Pós-Graduação em Ciências Farmacêuticas, 2010-04-16)
Sitagliptin Phosphate is an oral anti-hyperglycemic belonging to a new class of
medicine used in type 2 diabetes treatment, the dipeptidyl dipetidase -4 (DPP-4) enzyme
inhibitors. This drug besides being safe and tolerated, ...
Efeitos da sitagliptina no tecido ósseo em ratos diabéticos e não diabéticos
(Universidade Estadual Paulista (Unesp), 2018-05-30)
A diabetes mellitus, doença caracterizada pelo aumento da glicemia no sangue, é um dos mais importantes problemas de saúde pública do mundo, com incidência crescente, sobretudo em países em desenvolvimento. Novas terapias ...
Exenatide and sitagliptin decrease interleukin 1β, matrix metalloproteinase 9, and nitric oxide synthase 2 gene expression but does not reduce alveolar bone loss in rats with periodontitis
(Journal of Periodontology, 2015)
New drugs for the treatment of diabetes, glucagon-like peptide-1 (GLP-1) receptor agonists and inhibitors of dipeptidyl peptidase-4 (DPP-4) have shown pleiotropic effects on bone metabolism and anti-inflammatory properties. ...
Left ventricular diastolic function in patients with type 2 diabetes treated with a dipeptidyl peptidase-4 inhibitor- a pilot study
(2014-09-24)
Abstract
Background
Blood glucose control is fundamental albeit not enough to prevent diabetic macrovascular complications. Dipeptidyl peptidase-4 (DPP-4) inhibitors are ...
Sitagliptina, un inhibidor de la enzima DPP-IV, aumenta el colesterol plasmático total, altera el perfil de colesterol lipoproteico y disminuye el transporte reverso de colesterol en ratones
(2010)
Background: Insulin and glucagon regúlate the expression of key lipoprotein metabolism enzymes. Dyslipidemia is a significant risk factor for cardiovascular disease, the main cause of death in diabetic patients. Sitagliptine, ...