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State of the Art on Plant-Made Single-Domain Antibodies
(SciTechnol, 2014-08)
In addition to conventional antibodies (with heavy and light chains), camelids also produce functional antibodies devoid of light chains (HCAbs) without the first constant domain (CH1). Their variable domains (VHH) have ...
Single-domain antibodies and the promise of modular targeting in cancer imaging and treatment
(Frontiers Research Foundation, 2018-02)
Monoclonal antibodies and their fragments have significantly changed the outcome of cancer in the clinic, effectively inhibiting tumor cell proliferation, triggering antibody-dependent immune effector cell activation and ...
Controlling Rotavirus-associated diarrhea: Could single-domain antibody fragments make the difference?Hacia el control de la diarrea por rotavirus A: ¿podrían los nanoanticuerpos VHH marcar la diferencia?
(Asociación Argentina de Microbiología, 2015-10)
Los rotavirus del grupo A (RVA) constituyen la principal causa de diarrea grave y mortalidad infantil. La porción variable de los anticuerpos de cadena pesada derivados de camélidos presentan una amplia capacidad de unión ...
A PROTEOLYTIC FRAGMENT OF TRYPANOSOMA-CRUZI TRANS-SIALIDASE LACKING THE CARBOXYL-TERMINAL DOMAIN IS ACTIVE, MONOMERIC, AND GENERATES ANTIBODIES THAT INHIBIT ENZYMATIC-ACTIVITY
(Amer Soc Biochemistry Molecular Biology Inc, 1994-03-18)
trans-Sialidase isolated from trypomastigote forms of Trypanosoma cruzi, the protozoan parasite that causes Chagas' disease, is multimeric and heterogeneous in size. We show here that limited proteolysis of trans-sialidase ...
A Novel Single Domain Antibody Targeting FliC Flagellin of Salmonella enterica for Effective Inhibition of Host Cell Invasion
(Frontiers Media S.A., 2019-11)
The enteric pathogen, Salmonella enterica is a major cause of human gastroenteritis globally and with increasing bacterial resistance to antibiotics, alternative solutions are urgently needed. Single domain antibodies ...
A Proteolytic Fragment of Trypanosoma cruzi trans-Sialidase Lacking the Carboxyl-terminal Domain Is Active, Monomeric, and Generates Antibodies That Inhibit Enzymatic Activity
(American Society for Biochemistry and Molecular Biology, 2017)
Controlling Rotavirus-associated diarrhea: Could single-domain antibody fragments make the difference? = Hacia el control de la diarrea por rotavirus A: ¿podrían los nanoanticuerpos VHH marcar la diferencia?
(Asociación Argentina de Microbiología, 2015-10)
Group A Rotavirus (RVA) remains a leading cause of severe diarrhea and child mortality. The variable domain of camelid heavy chain antibodies (VHH) display potent antigen-binding capacity, have low production costs and are ...