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Scopolamine loaded in natural rubber latex as a future transdermal patch for sialorrhea treatment
(2019-09-02)
Sialorrhea is characterized by an increase in salivation. One of the adverse reactions of scopolamine is the decrease of salivary volume. Natural rubber latex can be used as a carrier matrix. This study developed and ...
Silent aspiration in Parkinson’s disease patients with diurnal sialorrhea
(2008)
Objective We studied the frequency of silent laryngeal penetration or silent aspiration (SLP/SA) in Parkinson's disease (PD) patients with diurnal sialorrhea.
Patients and methodn In 19 consecutive PD patients with diurnal ...
Design and development of a novel supportive care product for the treatment of sialorrhea in Parkinson's disease
(Bentham Science Publishers, 2015-03)
Sialorrhea or excessive drooling is a significant medical issue in Parkinson’s disease (PD) and neurodegenerative disorders, although it is often underreported by patients. Sialorrhea affects a large proportion of PD ...
Does botulinum toxin decrease frequency and severity of sialorrhea in Parkinson's disease?
(2007)
This study analysed if botulinum toxin type A (BTX-A) decreases drooling in 21 Parkinson's disease patients. BTX-A injections were given in the parotid glands. The severity of drooling decreased in 18 (86%) patients, while ...
Does botulinum toxin injection in parotid glands interfere with the swallowing dynamics of Parkinson's disease patients?
(2009)
Background: During recent years, sialorrhea in Parkinson's disease (PD) has been treated with botulinum toxin type A (BT-A); however, there are no data describing its effects on swallowing dynamics in this group of ...
Evaluation of acrylic acid grafting on the loading and release of scopolamine butylbromide from polymeric matrices for future sialorrhea treatment
(2021-04-05)
Sialorrhea is a disorder which causes an increase in salivation. Scopolamine butylbromide (SBB) can be administrated to treat sialorrhea and its transdermal application minimizes the occurrence of side effects. This work ...