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The structure and evolution of cisregulatory regions: The shavenbaby story
(The Royal Society, 2013-12)
In this paper, we provide a historical account of the contribution of a single line of research to our current understanding of the structure of cis-regulatory regions and the genetic basis for morphological evolution. We ...
Cis-regulatory variation in the shavenbaby gene underlies intraspecific phenotypic variation, mirroring interspecific divergence in the same trait
(Wiley Blackwell Publishing, Inc, 2020-12)
Despite considerable progress in recent decades in dissecting the genetic causes of natural morphological variation, there is limited understanding of how variation within species ultimately contributes to species differences. ...
Comprehensive Analysis of a cis-Regulatory Region Reveals Pleiotropy in Enhancer Function
(Elsevier, 2018-03)
Developmental genes can have complex cis-regulatory regions with multiple enhancers. Early work revealed remarkable modularity of enhancers, whereby distinct DNA regions drive gene expression in defined spatiotemporal ...
Estructura y función de la región regulatoria de la transcripción del gen shavenbaby en Drosophila melanogasterStructure and function of the cis-regulatory of shavenbaby gene in Drosophila melanogaster
(2018-03-16)
Los programas genéticos del desarrollo en organismos multicelulares son regulados por cambios en la expresión génica. Estos cambios determinan los procesos de diferenciación celular que suceden durante el desarrollo de los ...
Low Affinity Binding Site Clusters Confer Hox Specificity and Regulatory Robustness
(Cell Press, 2014-12)
In animals, Hox transcription factors define regional identity in distinct anatomical domains. How Hox genes encode this specificity is a paradox, because different Hox proteins bind with high affinity in vitro to similar ...
Gene regulatory network architecture in different developmental contexts influences the genetic basis of morphological evolution
(Public Library of Science, 2018-05-03)
Convergent phenotypic evolution is often caused by recurrent changes at particular nodes in the underlying gene regulatory networks (GRNs). The genes at such evolutionary ?hotspots? are thought to maximally affect the ...