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Astroglial mGlu3 receptors promote alpha-secretase-mediated amyloid precursor protein cleavage
(Elsevier, 2013-11)
Amyloid precursor protein (APP) shedding yields the Alzheimer´s disease (AD)-related peptide amyloid B (AB) through beta- and gamma-secretase cleavage. Alternatively, alpha-secretase cleavage generates a soluble and ...
Gamma secretase inhibitor impairs epithelial-to-mesenchymal transition induced by TGF-β in ovarian tumor cell lines
(Elsevier Ireland, 2017-01)
Ovarian cancer is characterized by being highly metastatic, a feature that represents the main cause of failure of the treatment. This study investigated the effects of γ-secretase inhibition on the TGF-β-induced ...
Adaptor protein 2-mediated endocytosis of the beta-secretase bace1 is dispensable for amyloid precursor protein processing
(AMERICAN SOCIETY FOR CELL BIOLOGY, 2012)
Alpha-secretase-derived fragment of cellular prion, n1, protects against monomeric and oligomeric amyloid beta (a beta)-associated cell death
(AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2012)
7-Amidocoumarins as Multitarget Agents against Neurodegenerative Diseases: Substitution Pattern Modulation
(John Wiley and Sons Ltd, 2020)
Alzheimer's disease: A review from the pathophysiology to diagnosis, new perspectives for pharmacological treatment
(2018-01-01)
Dementia is characterized by the impairment of cognition and behavior of people over 65 years. Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder in the world, as approximately 47 million people are ...