Buscar
Mostrando ítems 1-10 de 950
Caracterização dos parâmetros de sono e dos padrões epileptogênicos e comportamentais de animais geneticamente modificados com disfunções nos canais de sódio Scn8a e Scn1a
(Universidade Federal de São Paulo (UNIFESP), 2009-11-25)
Os canais de sódio dependentes de voltagem (CSDV) possuem um papel importante para a regulação da excitabilidade neuronal. Os CSDV SCN1A, SCN2A, SCN3A, e SCN8A, são principalmente expressos no sistema nervoso central. As ...
Gene variant effects across sodium channelopathies predict function and guide precision therapy
(2022)
Pathogenic variants in the voltage-gated sodium channel gene family lead to early onset epilepsies, neurodevelopmental disorders, skeletal muscle channelopathies, peripheral neuropathies and cardiac arrhythmias. ...
Altered sleep regulation in a mouse model of SCN1A-derived genetic epilepsy with febrile seizures plus (GEFS+)
(Wiley-Blackwell, 2013-04-01)
Purpose Mutations in the voltage-gated sodium channel (VGSC) gene SCN1A are responsible for a number of epilepsy disorders, including genetic epilepsy with febrile seizures plus (GEFS+) and Dravet syndrome. in addition to ...
Dissociation of circadian and light inhibition of melatonin release through forced desynchronization in the rat
(NATL ACAD SCIENCES, 2009)
Pineal melatonin release exhibits a circadian rhythm with a tight nocturnal pattern. Melatonin synthesis is regulated by the master circadian clock within the hypothalamic suprachiasmatic nucleus (SCN) and is also directly ...
Prevalência da mutação causadora da paralisia periódica hipercalêmica em equinos da raça Quarto de Milha no Brasil
(Universidade Federal de Santa Maria, 2015-05-01)
Hyperkalemic Periodic Paralysis (HYPP) is one of the major dominant genetic diseases which affect Quarter horses (QH). The HYPP is caused by a point mutation in the SCN4A gene and despite the presence of HYPP in Brazilian ...
SCN astrocytes modulate the circadian clock in response to TNF-α
(American Association of Immunologists, 2013-11)
The immune and the circadian systems interact in a bidirectional fashion. The master circadian oscillator, located in the suprachiasmatic nuclei of the hypothalamus (SCN), responds to peripheral and local immune stimuli, ...
Servicios de intermediación financiera medidos indirectamente (SIFMI) en el SCN 2008: grupo de trabajo en cuentas nacionales
(CEPAL, 2011-10)
El grupo de trabajo en Cuentas Nacionales del tema SIFMI (GT_CN- SIFMI) fue creado con el objetivo de contribuir a la implementación en la región de las recomendaciones del Sistema de Cuentas Nacionales 2008 (SCN 2008) en ...
Efeitos da senescência no núcleo supraquiasmático do sagui (Callithrix Jacchus): plasticidade morfológica e neuroquímica
(Universidade Federal do Rio Grande do NorteBRUFRNPrograma de Pós-Graduação em PsicobiologiaEstudos de Comportamento; Psicologia Fisiológica, 2013-06-21)
The circadian timing system (CTS) is responsible for the generation and
synchronization and the suprachiasmatic nucleus (SCN) of the hypothalamus has
been described as the major circadian pacemaker in many mammalian ...