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Promising inhibitors targeting Mpro: an ideal strategy for anti- SARS-CoV-2 drug discovery
Recently, Dai W et al. published a study on Science,1 in which
the two lead compounds 11a and 11b were designed and
synthesized based on the features of a key enzyme Mpro of SARSCoV-2 (Fig. 1). In particular, compound ...
Coagulation modifiers targeting SARS-CoV-2 main protease Mpro for COVID-19 treatment: an in silico approach
(Fundação Oswaldo Cruz. Instituto Oswaldo Cruz, 2020)
Coagulation modifiers targeting SARS-CoV-2 main protease Mpro for COVID-19 treatment
(Fundação Oswaldo Cruz. Instituto Oswaldo Cruz, 2020)
Susceptibility analysis of mutations that confer resistance to inhibitors of the main protease (Mpro) and RNA-dependent RNA polymerase (RdRp) of the SARS-CoV-2 virusSusceptibility analysis of mutations that confer resistance to inhibitors of the SARS-CoV-2 main protease (Mpro) and RNA-dependent RNA polymerase (RdRp)
(Universidad Técnica de Ambato - FCIAL, 2022)
COVID-19: in silico identification of potent α-ketoamide inhibitors targeting the main protease of the SARS-CoV-2
(2021)
The COVID-19 has been creating a global crisis, causing countless deaths and unbearable panic. Despite the progress made in the development of the vaccine, there is an urge need for the discovery of antivirals that may ...
In silico and in vitro studies of organoselenium compounds interaction with Mpro and PLpro from SARS-CoV-2
(Universidade Federal de Santa MariaBrasilBioquímicaUFSMPrograma de Pós-Graduação em Ciências Biológicas: Bioquímica ToxicológicaCentro de Ciências Naturais e Exatas, 2023-02-24)
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Avaliação de parâmetros cinéticos de diferentes construções da Mpro do vírus causador da COVID-19.
(Universidade Federal de São Paulo, 2022-06-21)
No começo de janeiro de 2020, especialistas constataram através de
sequenciamentos de genomas feitos em uma amostra de fluído bronco alveolar de
um paciente, a existência de um vírus da Familia Coronaviridae pertencente ...
An in silico analysis of Ibuprofen enantiomers in high concentrations of sodium chloride with SARS-CoV-2 main protease
(Taylor & Francis, 2021-01)
2020 will be remembered worldwide for the outbreak of Coronavirus disease (COVID-19), which quickly spread until it was declared as a global pandemic. The main protease (Mpro) of SARS-CoV-2, a key enzyme in coronavirus, ...