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The low molecular weight S-nitrosothiol, S-nitroso-N-acetylpenicillamine, promotes cell cycle progression in rabbit aortic endothelial cells
(Elsevier B.V., 2008-06-01)
S-Nitrosylation reactions are considered to be a major mechanism by which NO-related bioactivities are regulated in vivo. in the present study, we show the effects of the low molecular weight S-nitrosothiol, S-nitroso-N- ...
Critical contribution of Na+-Ca2+ exchanger to the Ca2+-mediated vasodilation activated in endothelial cells of resistance arteries
(2018)
Na+-Ca2+ exchanger (NCX) contributes to control the intracellular free Ca2+ concentration ([Ca2+](i)), but the functional activation of NCX reverse mode (NCXrm) in endothelial cells is controversial. We evaluated the ...
Human mesenchymal stem cells efficiently manage oxidative stress
(2010)
The transplantation of mesenchymal stem cells (MSCs) proves to be useful to treat pathologies in which tissue
damage is linked to oxidative stress (OS). The aim of our work was to evaluate whether primary human MSCs
(hMSCs) ...
Influence of nitric oxide and phosphodiesterases during in vitro maturation of bovine oocytes on meiotic resumption and embryo production
(2017-06-01)
This study aimed to examine the effects of nitric oxide (NO) and different phosphodiesterase (PDE) families on meiosis resumption, nucleotides levels and embryo production. Experiment I, COCs were matured in vitro with the ...
Nitrosative/Oxidative Stress Conditions Regulate Thioredoxin-Interacting Protein (TXNIP) Expression and Thioredoxin-1 (TRX-1) Nuclear Localization
(Public Library Science, 2013-12-20)
Thioredoxin (TRX-1) is a multifunctional protein that controls the redox status of other proteins. TRX-1 can be found in the extracellular milieu, cytoplasm and nucleus, and it has distinct functions in each environment. ...
Interleukin-1ß regulates nitric oxide production and gamma-glutamyltranspeptidase activity in Sertoli cells
(American Society of Andrology, 2000-12)
Several cytokines have been involved in the regulation of Sertoli cell function. Further investigations are required to elucidate the role of interleukin-1beta (IL1beta) in Sertoli cell physiology. Twenty-day-old rat ...
Don't just say no: Differential pathways and pharmacological responses to diverse nitric oxide donors
(Pergamon-Elsevier Science Ltd, 2018-10)
Nitric oxide (NO[rad]) is a gaseous free radical molecule with a short half-life (∼1 s), which can gain or lose an electron into three interchangeable redox-dependent forms, the radical (NO[rad]), the nitrosonium cation ...
Nitric oxide and cGMP activate the Ras-MAP kinase pathway-stimulating protein tyrosine phosphorylation in rabbit aortic endothelial cells
(Elsevier B.V., 2003-08-15)
The free radical nitric oxide is a very effective signal transducer, stimulating the enzyme guanylyl cyclase, the oncoprotein p21Ras, and protein tyrosine phosphorylation. in the present study using rabbit aortic endothelial ...