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Paracoccidioidomycosis Associated With a Heterozygous STAT4 Mutation and Impaired IFN-gamma Immunity
(Oxford Univ Press Inc, 2017-12-15)
Background. Mutations in genes affecting interferon-gamma (IFN-gamma) immunity have contributed to understand the role of IFN-gamma in protection against intracellular pathogens. However, inborn errors in STAT4, which ...
Ciliary Neurotrophic Factor Protects Mice Against Streptozotocin-induced Type 1 Diabetes through SOCS3 THE ROLE OF STAT1/STAT3 RATIO IN beta-CELL DEATH
(Amer Soc Biochemistry Molecular Biology IncBethesdaEUA, 2012)
Expression of suppressor of cytokine signaling 1 and 3 in ligature-induced periodontitis in rats
(Pergamon-Elsevier B.V. Ltd, 2011-10-01)
Objective: : Evaluate expression of inducible negative regulators of JAK/STAT pathway and their target proteins during the course of ligature-induced experimental periodontal disease in rats.Design: : Rats were sacrificed ...
Expression of suppressor of cytokine signaling 1 and 3 in ligature-induced periodontitis in rats
(Pergamon-Elsevier B.V. Ltd, 2011-10-01)
Objective: : Evaluate expression of inducible negative regulators of JAK/STAT pathway and their target proteins during the course of ligature-induced experimental periodontal disease in rats.Design: : Rats were sacrificed ...
Inhibition of Stat3 Activation Suppresses Caspase-3 and the Ubiquitin-Proteasome System, Leading to Preservation of Muscle Mass in Cancer Cachexia
(Amer Soc Biochemistry Molecular Biology Inc, 2015-04-24)
Cachexia occurs in patients with advanced cancers. Despite the adverse clinical impact of cancer-induced muscle wasting, pathways causing cachexia are controversial, and clinically reliable therapies are not available. A ...
Ciliary neurotrophic factor (CNTF) signals through STAT3-SOCS3 pathway and protects rat pancreatic islets from cytokine-induced apoptosis
(Academic Press Ltd- Elsevier Science LtdLondonInglaterra, 2009)
SOCS3 expression correlates with severity of inflammation, expression of proinflammatory cytokines, and activation of STAT3 and p38 MAPK in LPS-induced inflammation in vivo
(2013-10-07)
SOCS3 is an inducible endogenous negative regulator of JAK/STAT pathway, which is relevant in inflammatory conditions. We used a model of LPS-induced periodontal disease in rats to correlate SOCS3 expression with the ...
SOCS3 expression correlates with severity of inflammation, expression of proinflammatory cytokines, and activation of STAT3 and p38 MAPK in LPS-induced inflammation in vivo
(2013-10-07)
SOCS3 is an inducible endogenous negative regulator of JAK/STAT pathway, which is relevant in inflammatory conditions. We used a model of LPS-induced periodontal disease in rats to correlate SOCS3 expression with the ...
Ativação das STAT-1, STAT-3 e STAT-6 na modulação da coinfecção com duas cepas de Trypanosoma cruzi em macrófagos humanos polarizados M1 e M2
(Universidade Federal de São Paulo, 2022-02-08)
A interação do parasito Trypanosoma cruzi (T. cruzi), agente etiológico da doença de Chagas, com o sistema imunológico do indivíduo infectado é um fator determinante no curso da doença. A resposta imune é, em geral, apta ...