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Activation of RyR2 by class I kinase inhibitors
(Wiley Blackwell Publishing, Inc, 2018-12-26)
Background and Purpose: Kinase inhibitors are a common treatment for cancer. Class I kinase inhibitors that target the ATP-binding pocket are particularly prevalent. Many of these compounds are cardiotoxic and can cause ...
Molecular cloning of αRYR hotspot region 1 from broiler chicken
(Tecpar, 2009)
Samples of Pectoralis major m. were collected, and an RT-PCR analysis of the a-Ryanodine receptor (a RYR) from chicken mRNA hotspot region spanning aminoacid residues 386 to 540, numbered according to the turkey sequence, ...
Dusty core disease' (DuCD): expanding morphological spectrum of RYR1 recessive myopathies
(2019)
Several morphological phenotypes have been associated to RYR1-recessive myopathies. We recharacterized the RYR1-recessive morphological spectrum by a large monocentric study performed on 54 muscle biopsies from a large ...
RyR1-mediated Ca2+ Leak and Ca2+ Entry Determine Resting Intracellular Ca2+ in Skeletal Myotubes
(American Society for Biochemistry and Molecular Biology, Inc., 2010-04-30)
The control of resting free Ca2+ in skeletal muscle is thought
to be a balance of channels, pumps, and exchangers in both the
sarcolemma and sarcoplasmic reticulum. We explored these
mechanisms using pharmacologic and ...
Comida al Paso Ryr
(2020)
Mecanismos de degradación del receptor de ryanodina tipo 2 : participación de la autofagia mediada por cheperonas
(Universidad de Chile, 2011-12)
El receptor de ryanodina tipo 2 (RyR2) desempeña un papel crucial en el corazón ya que permite la salida de calcio desde el retículo sarcoplasmático para activar la contracción, por tanto la regulación de sus niveles es ...
Functional implications of RyR-DHPR relationships in skeletal and cardiac muscles
(Sociedad de Biología de Chile, 2004)
RyR2-Mediated Ca2+ Release and Mitochondrial ROS Generation Partake in the Synaptic Dysfunction Caused by Amyloid beta Peptide Oligomers
(2017)
Amyloid beta peptide oligomers (A beta Os), toxic aggregates with pivotal roles in Alzheimer's disease, trigger persistent and low magnitude Ca2+ signals in neurons. We reported previously that these Ca2+ signals, which ...
Stimulation of NOX2 in isolated hearts reversibly sensitizes RyR2 channels to activation by cytoplasmic calcium
(Elsevier, 2014-03)
The response of ryanodine receptor (RyR) channels to cytoplasmic free calcium concentration ([Ca2 +]) is redox sensitive. Here, we report the effects of a mild oxidative stress on cardiac RyR (RyR2) channels in Langendorff ...