Buscar
Mostrando ítems 1-9 de 9
Insights into the non-coding RNome of nitrogen-fixing endosymbiotic α-proteobacteria
(American Phytopathological Society, 2013-02)
Symbiotic chronic infection of legumes by rhizobia involves transition of invading bacteria from a free-living environment in soil to an intracellular state as differentiated nitrogen-fixing bacteroids within the nodules ...
Who's the boss here? The post-transcriptional global regulator Hfq takes over control of secondary metabolite production in the nematode symbiont Photorhabdus luminiscens
(Wiley Blackwell Publishing, Inc, 2017-01)
A Trojan? Dr. Jekyll and Mr. Hyde? This is Photorhabdus luminiscens: an enterobacterial symbiont of nematodes of the Heterorhabditis genus, and, at the same time, an insect killer. It colonizes the nematode gut; the worm ...
Regulation of polyhydroxybutyrate accumulation in Sinorhizobium meliloti by the trans-encoded small RNA MmgR
(American Society for Microbiology, 2017-01)
Riboregulation has a major role in the fine-tuning of multiple bacterial processes. Among the RNA players, trans-encoded untranslated small RNAs (sRNAs) regulate complex metabolic networks by tuning expression from multiple ...
Expression of the small regulatory RNA gene mmgR is regulated negatively by AniA and positively by NtrC in Sinorhizobium meliloti 2011
(Society for General Microbiology, 2017-12)
In the N2-fixing symbiont of alfalfa root nodules, Sinorhizobium meliloti 2011, the mmgR gene encodes a 77 nt small untranslated RNA (sRNA) that negatively regulates the accumulation of polyhydroxybutyrate (PHB) when the ...
Expression of the Sinorhizobium meliloti small RNA gene mmgR is controlled by the nitrogen source
(Wiley Blackwell Publishing, Inc, 2016-04)
Small non-coding regulatory RNAs (sRNAs) are key players in post-transcriptional regulation of gene expression. Hundreds of sRNAs have been identified in Sinorhizobium meliloti, but their biological function remains unknown ...
A CsrA/RsmA translational regulator gene encoded in the replication region of a Sinorhizobium meliloti cryptic plasmid complements Pseudomonas fluorescens rsmA/E mutants
(Society for General Microbiology, 2012-11)
Members of the CsrA/RsmA family are global regulatory proteins that bind to mRNAs, usually at the ribosome-binding site, to control mRNA translation and stability. Their activity is counteracted by small non-coding RNAs ...
Reprogramação do metabolismo de purina na bactéria Bacillus subtilis por tecnologia de pequenos RNAs não codificadores (sRNAs)
(Universidade Estadual Paulista (Unesp), 2019-07-25)
As técnicas mais usadas atualmente para alterar o fluxo metabólico por uma determinada via são a deleção e/ou inserção de sequências regulatórias ou genes no cromossomo bacteriano. Estes são métodos que alteram permanentemente ...
Construção de um sistema de amplificação de sinal para riboreguladores
(Universidade Estadual Paulista (Unesp), 2021-06-28)
Dengue e Zika são arbovírus do gênero Flavivirus e representam um risco de infecção para milhões de pessoas no mundo. Em 2019, o número de casos prováveis para essas doenças no Brasil aumentou 650% no caso da Dengue e 65% ...
Predicting Target-Ligand Interactions with Graph Convolutional Networks for Interpretable Pharmaceutical Discovery
(Universidad de los AndesMaestría en Ingeniería BiomédicaFacultad de IngenieríaDepartamento de Ingeniería Biomédica, 2022-06-06)
Drug Discovery is an active research area that demands great investments and generates low returns due to its inherent complexity and great costs. To identify potential therapeutic candidates more effectively, we propose ...