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Inflammation and oxidative stress in retinal diseases: the role of intracellular signaling in the retinal pigment epithelium
(ClinMed International Library, 2015-08)
The retinal pigment epithelium (RPE) is essential for the integrity and function of the retina. RPE cells exert key functions to maintain photoreceptors´ (PRs) viability and functionality, such as light absorption and ...
Phospholipase D1 modulates protein kinase C-epsilon in retinal pigment epithelium cells during inflammatory response
(Pergamon-Elsevier Science Ltd, 2016-10)
Inflammation is a key factor in the pathogenesis of several retinal diseases. In view of the essential role of the retinal pigment epithelium in visual function, elucidating the molecular mechanisms elicited by inflammation ...
Druse-Induced Morphology Evolution in Retinal Pigment Epithelium
(Cornell University, 2016-09)
The retinal pigment epithelium (RPE) is a key site of pathogenesis for many retina diseases. The formation of drusen in the retina is characteristic of retinal degeneration. We investigate morphological changes in the RPE ...
The phospholipase D pathway mediates the inflammatory response of the retinal pigment epithelium
(Pergamon-elsevier Science Ltd, 2014-08)
The retinal pigment epithelium (RPE) plays an important immunological role in the retina and it is involved in many ocular inflammatory diseases that may end in loss of vision and blindness. In this work the role of ...
Diagnostic and Therapeutic Challenges
(Lippincott Williams & Wilkins, 2017)
Ocular masquerade syndrome due to intraocular lymphoma - two forms of retinal pigment epithelium involvement: case reports
(Conselho Brasileiro de Oftalmologia, 2007-06-01)
Ocular masquerade syndrome was diagnosted in two patients with chronic uveitis. The patients presented non-Hodgkin's lymphoma as the final diagnosis two forms of intraocular retinal pigment epithelium involvement was seen. ...
Fundus flavimaculatus e neovascularização subretiniana: relato de caso
(Conselho Brasileiro de Oftalmologia, 2005-04-01)
Fundus flavimaculatus is a progressive, bilateral, hereditary retinal dystrophy characterized by ill-defined, yellowish, pisciform flecks at the level of the retinal pigment epithelium. Since the disease process is at level ...
Antiviral bioactivity of resveratrol against Zika virus infection in human retinal pigment epithelial cells
(Springer, 2021-07)
Resveratrol (RES) is a polyphenol with increasing interest for its inhibitory effects on a wide variety of viruses. Zika virus (ZIKV) is an arbovirus which causes a broad spectrum of ophthalmological manifestations in ...
Effect of Toxoplasma gondii infection on the junctional complex of retinal pigment epithelial cells
(Cambridge University Press, 2016)