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Positive selection results in frequent reversible amino acid replacements in the G protein gene of human respiratory syncytial virus
(2009-01-01)
Human respiratory syncytial virus (HRSV) is the major cause of lower respiratory tract infections in children under 5 years of age and the elderly, causing annual disease outbreaks during the fall and winter. Multiple ...
Positive selection results in frequent reversible amino acid replacements in the G protein gene of human respiratory syncytial virus
(2009-01-01)
Human respiratory syncytial virus (HRSV) is the major cause of lower respiratory tract infections in children under 5 years of age and the elderly, causing annual disease outbreaks during the fall and winter. Multiple ...
Mechanism of Tetramer Dissociation, Unfolding, and Oligomer Assembly of Pneumovirus M2-1 Transcription Antiterminators
(American Chemical Society, 2018-11)
Among Mononegavirales, the Pneumovirus family stands out by its RNA polymerase processivity that relies on a transcription antiterminator, the M2-1 protein, which also plays a key role in viral particle assembly. Biophysical ...
Recombinant BCG Vaccines Reduce Pneumovirus-Caused Airway Pathology by Inducing Protective Humoral Immunity
(2018)
The Human Respiratory Syncytial Virus (hRSV) and the Human Metapneumovirus (hMPV) are two pneumoviruses that are leading agents causing acute lower respiratory tract infections (ALRTIs) affecting young infants, the elderly, ...
Recombinant BCG Vaccines Reduce Pneumovirus-Caused Airway Pathology by Inducing Protective Humoral Immunity
(2018)
The Human Respiratory Syncytial Virus (hRSV) and the Human Metapneumovirus (hMPV) are two pneumoviruses that are leading agents causing acute lower respiratory tract infections (ALRTIs) affecting young infants, the elderly, ...
Cooperative RNA Recognition by a Viral Transcription Antiterminator
(Academic Press Ltd - Elsevier Science Ltd, 2018-03)
RNA transcription of mononegavirales decreases gradually from the 3′ leader promoter toward the 5′ end of the genome, due to a decay in polymerase processivity. In the respiratory syncytial virus and metapneumovirus, the ...