Buscar
Mostrando ítems 1-10 de 17
Identification of cisapride as new inhibitor of putrescine uptake in Trypanosoma cruzi by combined ligand- and structure-based virtual screening
(Elsevier France-editions Scientifiques Medicales Elsevier, 2018-04-10)
Nowadays, the pharmacological therapy for the treatment of Chagas disease is based on two old drugs, benznidazole and nifurtimox, which have restricted efficacy against the chronic phase of the illness. To overcome the ...
Crystal violet structural analogues identified by in silico drug repositioning present anti-Trypanosoma cruzi activity through inhibition of proline transporter TcAAAP069
(Public Library of Science, 2020-01)
Background: Crystal violet (CV) was used for several years in blood banks to eliminate the parasite Trypanosoma cruzi in endemic areas in order to prevent transfusiontransmitted Chagas disease. One mechanism of action ...
Crystal violet chemical analogues identified by computational drug repositioning present anti-Trypanosoma cruzi activity through inhibition of the proline transporter TcAAAP069
(Public Library of Science, 2020-01-21)
Background: Crystal violet (CV) was used for several years in blood banks to eliminate the parasite Trypanosoma cruzi in endemic areas in order to prevent transfusion-transmitted Chagas disease. One mechanism of action ...
Combating COVID-19: The role of drug repurposing and medicinal plants
Background:A novel corona virus-2 disease has spread to 213 countries and territories across the globe.
The corona pandemic has claimed more than 548,934 deaths worldwide till the evening of 8
th of July 2020
and the ...
Discovery of novel falcipain 2 inhibitors by in silico guided drug repositioning
(University of Dundee, 2019)
Malaria is a life-threatening condition that continues being one of global leading causes of death worldwide, being themain cause of death globally in the 5-14 year-old population. The disease is caused by parasites from ...
Cheaper Faster Drug Development Validated By The Repositioning Of Drugs Against Neglected Tropical Diseases
(Royal Society of London, 2015)
Coumarins: old compounds with novel promising therapeutic perspectives
(Bentham Science Publishers, 2010-12)
Natural as well as synthetic coumarins have recently drawn much attention due to its broad pharmacological activities. Many coumarins and their derivatives exert anti-coagulant, anti-tumor, anti-viral, anti-inflammatory ...