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Roles of the mitochondrial replisome in mitochondrial DNA deletion formation
(Soc Brasil Genetica, 2020-01-01)
Mitochondrial DNA (mtDNA) deletions are a common cause of human mitochondrial diseases. Mutations in the genes encoding components of the mitochondrial replisome, such as DNA polymerase gamma (Pol gamma) and the mtDNA ...
Animal Mitochondrial DNA Replication
(2016-01-01)
Recent advances in the field of mitochondrial DNA (mtDNA) replication highlight the diversity of both the mechanisms utilized and the structural and functional organization of the proteins at mtDNA replication fork, despite ...
Structural rearrangements in the mitochondrial genome of Drosophila melanogaster induced by elevated levels of the replicative DNA helicase
(Oxford Univ Press, 2018-04-06)
Pathological conditions impairing functions of mitochondria often lead to compensatory upregulation of the mitochondrial DNA (mtDNA) replisome machinery, and the replicative DNA helicase appears to be a key factor in ...
The Tip of an Iceberg: Replication-Associated Functions of the Tumor Suppressor p53.
(MDPI, 2018-07)
The Tip of an Iceberg: Replication-Associated Functions of the Tumor Suppressor p53.Gottifredi V1, Wiesmüller L2.The tumor suppressor p53 is a transcriptional factor broadly mutated in cancer. Most inactivating and gain ...
Caracterización de la fibra del pseudo tallo de plátano como refuerzo y desarrollo de un material compuesto para fabricación de tejas
(Universidad Pedagógica y Tecnológica de ColombiaEscuela de Diseño IndustrialFacultad Seccional Duitama, 2019)
El cultivo del plátano, es considerado el cuarto cultivo más importante a nivel mundial. De la planta del plátano solo el 12% se considera comerciable, que es el fruto. El 88% restante se considera residuo, pero los ...