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Generation of a DNA-Launched Reporter Replicon Based on Dengue Virus Type 2 as a Multipurpose Platform
(KargerGrupo Medicina Molecular y de TranslaciónBasilea, Suiza, 2021)
Ensaios celulares baseados em replicon de Chikungunya para identificação de antivirais
(Universidade Federal de São CarlosUFSCarCâmpus São CarlosBiotecnologia - Biotec, 2022-04-12)
Chikungunya virus (CHIKV), which causes Chikungunya fever, is a arbovirus transmitted by the Aedes aegypti mosquito, which periodically causes epidemics around the world and can become a serious public health problem. ...
Desenvolvimento e aplicação biotecnológica de replicons repórteres para triagem de drogas antivirais contra o vírus da febre amarela
(Universidade Federal de Pernambuco, 2014)
Synthesis of new indanyl nucleoside analogues and their biological evaluation on hepatitis C virus (HCV) replicon
(Molecular Diversity Preservation International, 2019-03)
Here, we report a convenient synthetic procedure for the preparation of four novel indanyl carbanucleoside derivatives in the racemic form. The action of these compounds against hepatitis C virus was evaluated in vitro ...
Relevance of the N-terminal and major hydrophobic domains of non-structural protein 3A in the replicative process of a DNA-launched foot-and-mouth disease virus replicon
(Springer Wien, 2018-07)
A foot-and-mouth disease virus (FMDV) DNA-launched reporter replicon containing a luciferase gene was used to assess the impact of non-structural (NS) protein 3A on viral replication. Independent deletions within the ...
Insights into the unique characteristics of hepatitis C virus genotype 3 revealed by development of a robust sub-genomic DBN3a replicon
(Microbiology Soc, 2020-01-01)
Hepatitis C virus (HCV) is an important human pathogen causing 400 000 chronic liver disease-related deaths annually. Until recently, the majority of laboratory-based investigations into the biology of HCV have focused on ...