Eukaryote nuclear genomes predominantly replicate through multiple replication origins. The number of replication origins activated per chromosome during the S-phase duration may vary according to many factors, but the ...

The effectiveness of checkpoint kinase 1 (Chk1) inhibitors at killing cancer cells is considered to be fully dependent on their effect on DNA replication initiation. Chk1 inhibition boosts origin firing, presumably limiting ...

Replication fork progression is being continuously hampered by exogenously introduced and naturally occurring DNA lesions and other physical obstacles. Checkpoint kinase 1 (Chk1) is activated at replication forks that ...

The plastid and nuclear genomes of parasitic plants exhibit deeply altered architectures,1–13 whereas the few examined mitogenomes range from deeply altered to conventional.14–20 To provide further insight on mitogenome ...

To understand the mechanism of replication used by baculoviruses, it is essential to describe all the factors involved, including virus and host proteins and the sequences where DNA synthesis starts. A lot of work on this ...

Background Statistical methods for estimating usual intake require at least two short-term dietary measurements in a subsample of the target population. However, the percentage of individuals with a second dietary measurement ...

The parasites belonging to the family Trypanosomatidae (order Kinetoplastida) are among the most primitive eukaryotes. Some trypanosomatids are the etiologic agents of neglected human pathologies such as South American and ...