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Estimation of the Minimum Number of Replication Origins Per Chromosome in any Organism
(Bio-protocol, 2020-10-20)
Eukaryote nuclear genomes predominantly replicate through multiple replication origins. The number of replication origins activated per chromosome during the S-phase duration may vary according to many factors, but the ...
Exploring RNA Virus Replication in Xenopus Oocytes
(Humana Press, 2006)
Microinjection of poliovirus RNA in Xenopus oocytes initiates a complete and authentic viral replication cycle that yields newly synthesized infectious virus. This system can be used to study the molecular mechanism of the ...
MutS regulates access of the error-prone DNA polymerase Pol IV to replication sites: a novel mechanism for maintaining replication fidelity
(Oxford University Press, 2016-09)
Translesion DNA polymerases (Pol) function in the bypass of template lesions to relieve stalled replication forks but also display potentially deleterious mutagenic phenotypes that contribute to antibiotic resistance in ...
Power of redundancy: Designing partial replication for multi-tier applications
Replicating redundant requests has been shown to be an effective mechanism to defend application performance from high capacity variability - the common pitfall in the cloud. While the prior art centers on single-tier ...
How do host restriction factors influence dengue virus replication?
(Future Medicine, 2016-12)
Nuclear actin and myosins in adenovirus infection
(Elsevier Inc, 2015-11)
Adenovirus serotypes have been shown to cause drastic changes in nuclear organization, including the transcription machinery, during infection. This ability of adenovirus to subvert transcription in the host cell facilitates ...
The nerve growth factor reduces APOBEC3G synthesis and enhances HIV-1 transcription and replication in human primary macrophages
(The American Society of Hematology, 2016)
Virus-Host Interactions Involved in Lassa Virus Entry and Genome Replication
(Multidisciplinary Digital Publishing Institute, 2019-01)
Lassa virus (LASV) is the causative agent of Lassa fever, a human hemorrhagic disease associated with high mortality and morbidity rates, particularly prevalent in West Africa. Over the past few years, a significant amount ...
Structural rearrangements in the mitochondrial genome of Drosophila melanogaster induced by elevated levels of the replicative DNA helicase
(Oxford Univ Press, 2018-04-06)
Pathological conditions impairing functions of mitochondria often lead to compensatory upregulation of the mitochondrial DNA (mtDNA) replisome machinery, and the replicative DNA helicase appears to be a key factor in ...
RPA-1 from Leishmania amazonensis (LaRPA-1) structurally differs from other eukaryote RPA-1 and interacts with telomeric DNA via its N-terminal OB-fold domain
(Elsevier B.V., 2014-12-20)
Replication protein A-1 (RPA-1) is a single-stranded DNA-binding protein involved in DNA metabolism. We previously demonstrated the interaction between LaRPA-1 and telomeric DNA. Here, we expressed and purified truncated ...