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Reporter assays
(Humana Press, 2007-12)
Transcriptional feedback loops are at the core of the molecular clockworks. As single clock genes were cloned it was compelling to develop an assay that allowed simple and direct functional testing of putative activators ...
Construction and application of a built-in dual luciferase reporter for microRNA functional analysis
(Pontificia Universidad Católica de Valparaíso, 2011)
High D-glucose reduces promoter activity of human equilibrative nucleoside transporter 1 in human umbilical vein endothelium
(2006)
Reduction of adenosine uptake by human equilibrative membrane transporters 1 (hENT1) in human umbilical vein endothelial cells (HUVEC) from gestational diabetes, or in HUVEC from normal pregnancies exposed to high extracellular ...
The 5'-untranslated region of the mouse mammary tumor virus mRNA exhibits cap-independent translation initiation
(OXFORD UNIV PRESS, 2010)
In this study, we demonstrate the identification of an internal ribosome entry site (IRES) within the 5'-untranslated region (5'-UTR) of the mouse mammary tumor virus (MMTV). The 5'-UTR of the full-length mRNA derived from ...
The 5’ untranslated region of the anti-apoptotic protein Survivin contains an inhibitory upstream AUG codon
(Elsevier, 2020)
Survivin (BIRC5) is an anti-apoptotic protein that is important in cancer. Mechanisms responsible for controlling Survivin levels in cells include transcriptional regulation and modulation of protein stability via ...
Avaliação funcional de polimorfismos do oncogene E6 do Papilomavírus humano 31Avaliação funcional de polimorfismos do oncogenese E6 do Papilomavírus humano 31
(Universidade Federal de PernambucoUFPEBrasilPrograma de Pos Graduacao em Inovacao Terapeutica, 2019)
siRNA modified with 2′-deoxy-2′-c-methylpyrimidine nucleosides
(Wiley VCH Verlag, 2018-03)
(2′S)-2′-Deoxy-2′-C-methyluridine and (2′R)-2′-deoxy-2′-C-meth-yluridine were incorporated in the 3’-overhang region of the sense and antisense strands and in positions 2 and 5 of the seed region of siRNA duplexes directed ...
Insulin requires A2B adenosine receptors to modulate the L-arginine/nitric oxide signalling in the human fetoplacental vascular endothelium from late-onset preeclampsia
(2021-01-01)
Late-onset preeclampsia (LOPE) associates with reduced umbilical vein reactivity and endothelial nitric oxide synthase (eNOS) activity but increased human cationic amino acid (hCAT-1)–mediated L-arginine transport involving ...
Hypoxia increases equilibrative nucleoside transporter 2 activity by a transcriptional independent mechanism in human umbilical vein endothelium
(2006)
Low oxygen tension (hypoxia) reduces adenosine transport in several types of mammalian cells. Adenosine transport is mediated by human equilibrative nucleoside transporter 1 (hENT1) and hENT2 in human umbilical vein ...