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Confronting the barriers to develop novel vaccines against brucellosis
(Expert Reviews, 2011-09)
Brucellosis is an important zoonotic disease of nearly worldwide distribution. This pathogen causes abortion in domestic animals and undulant fever, arthritis, endocarditis and meningitis in humans. Currently, there is no ...
Boosting systemic and secreted antibody responses in mice orally immunized with recombinant Bacillus subtilis strains following parenteral priming with a DNA vaccine encoding the enterotoxigenic Escherichia coli (ETEC) CFA/I fimbriae B subunit
(ELSEVIER SCI LTD, 2008)
Recombinant Bacillus subtilis strains, either spores or vegetative cells, may be employed as safe and low cost orally delivered live vaccine vehicles. In this study, we report the use of an orally delivered B. subtilis ...
Advances in novel vaccines for foot and mouth disease: focus on recombinant empty capsids
(Taylor & Francis, 2019-01)
Foot and mouth disease (FMD) is a highly contagious disease of cloven-hoofed animals, which causes severe economic losses in the livestock industry. Currently available vaccines are based on inactivated FMD virus (FMDV). ...
A DNA vaccine candidate encoding the structural prM/E proteins elicits a strong immune response and protects mice against dengue-4 virus infection
(ELSEVIER SCI LTD, 2011)
A DNA vaccine expressing dengue-4 virus premembrane (prM) and envelope (E) genes was produced by inserting these genes into a mammalian expression plasmid (pCI). Following a thorough screening, including confirmation of ...
Recombinant and epitope-based vaccines on the road to the market and implications for vaccine design and production
(2016-03-03)
Novel vaccination approaches based on rational design of B- and T-cell epitopes - epitope-based vaccines - are making progress in the clinical trial pipeline. The epitope-focused recombinant protein-based malaria vaccine ...
Head-to-Head Comparison of Three Vaccination Strategies Based on DNA and Raw Insect-Derived Recombinant Proteins against Leishmania
(PUBLIC LIBRARY SCIENCESAN FRANCISCO, 2012)
Parasitic diseases plague billions of people among the poorest, killing millions annually, and causing additional millions of disability-adjusted life years lost. Leishmaniases affect more than 12 million people, with over ...
Chagas disease vaccine design: the search for an efficient Trypanosoma cruzi immune-mediated control
(Elsevier Science, 2020-05)
Chagas disease is currently endemic to 21 Latin-American countries and has also become a global concern because of globalization and mass migration of chronically infected individuals. Prophylactic and therapeutic vaccination ...
Delivery of recombinant vaccines against bovine herpesvirus type 1 and Babesia bovis to mice using liposomes derived from egg yolk lipids
(Elsevier, 2013-06)
Liposomes prepared from total egg yolk lipid extracts were used to deliver experimental DNA vaccines to mice consisting of pCI-neo plasmids encoding bovine herpesvirus type 1 (BoHV-1) gD or Babesia bovis MSA-2c. A significantly ...
Construção e caracterização de recombinante do herpesvírus bovino tipo 1 com deleção da glicoproteína E para uso em vacina
(Universidade Federal de Santa MariaBRMedicina VeterináriaUFSMPrograma de Pós-Graduação em Medicina Veterinária, 2015-02-27)
Vaccines with antigenic markers also known as differential vaccines have been largely used for control and prevention of bovine herpesvirus 1 (BoHV-1) infection. With this purpose, a Brazilian BoHV-1 isolate (SV56/90) ...
Seroconversion in response to a reinforced primary hepatitis B vaccination in children with cancer Seroconversión frente a primovacunación reforzada contra hepatitis B en ninos con cáncer
(Sociedad Chilena de Pediatria, 2015)
© 2015 Sociedad Chilena de Pediatría.Introduction: Immune response against vaccine antigens may be impaired in children with cancer. The aim of this study was to evaluate the seroconversion response against hepatitis B ...