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Diverging mechanisms of activation of chemokine receptors revealed by novel chemokine agonists

Autor desconocido (Public Library of Science, 2011)

CXCL8/interleukin-8 is a pro-inflammatory chemokine that triggers pleiotropic responses, including inflammation, angiogenesis, wound healing and tumorigenesis. We engineered the first selective CXCR1 agonists on the basis ...

Expressão e função de CXCR7 em sídromes mielodisplásicas e leucemiasExpression and function of CXCR7 in myelodysplastic syndromes and leukemias

Melo, Rita de Cássia Carvalho, 1988- ([s.n.], 2012)

CXCR3 chemokine receptor contributes to specific CD8+ T cell activation by pDC during infection with intracellular pathogens

Ferreira, Camila Pontes; Cariste, Leonardo de Moro; Noronha, Isaú Henrique; Durso, Danielle Fernandes; Lannes-Vieira, Joseli; Bortoluci, Karina Ramalho; Ribeiro, Daniel Araki; Golenbock, Douglas; Gazzinelli, Ricardo Tostes; Vasconcelos, José Ronnie Carvalho de (Public Library of Science, 2020)

Differential expression profile of CXCR3 splicing variants is associated with thyroid neoplasia. Potential role in papillary thyroid carcinoma oncogenesis?

Gamboa S.U.; Fischer M.C.; Martínez J.R.; Véliz L.; Orellana P.; Solar A.; Bohmwald K.; Kalergis A.; Riedel C.; Corvalán A.H.; Roa J.C.; Fuentealba R.; Cáceres C.J.; López-Lastra M.; León A.; Droppelmann N.; González H.E. (Impact Journals LLC, 2018)

Modulation of host antiviral restriction factors by ccr5 and cxcr4 ligands

Silva, Thauane; Vale, Gabrielle do; Ferreira, André; Bou-Habib, Dumith; Siqueira, Marilda Agudo Mendonça Teixeira de; Lopes, Thiago Moreno; Miranda, Milene (Fiocruz/Instituto de Tecnologia em Imunobiológicos, 2019)

Receptor binding mode and pharmacological characterization of a potent and selective dual CXCR1/CXCR2 non-competitive allosteric inhibitor

Bertini, R.; Barcelos, L. S.; Beccari, A. R.; Cavalieri, B.; Moriconi, A.; Bizzarri, C.; Di Benedetto, P.; Di Giacinto, C.; Gloaguen, I.; Galliera, E.; Corsi, M. M.; Russo, R. C.; Andrade, S. P.; Cesta, M. C.; Nano, G.; Aramini, A.; Cutrin, Juan Carlos; Locati, M.; Allegretti, M.; Teixeira, M. M. (Wiley Blackwell Publishing, Inc, 2012-01)

Background and Purpose: DF 2156A is a new dual inhibitor of IL-8 receptors CXCR1 and CXCR2 with an optimal pharmacokinetic profile. We characterized its binding mode, molecular mechanism of action and selectivity, and ...

Blockade of the chemokine receptor CXCR2 ameliorates adjuvant-induced arthritis in rats

BARSANTE, M. M.; CUNHA, T. M.; ALLEGRETTI, M.; CATTANI, F.; POLICANI, F.; BIZZARRI, C.; TAFURI, W. L.; POOLE, S.; CUNHA, F. Q.; BERTINI, R.; TEIXEIRA, M. M. (NATURE PUBLISHING GROUP, 2008)

Background and purpose: Chemokine receptors CXCR1 and CXCR2 may mediate influx of neutrophils in models of acute and chronic inflammation. The potential benefits of oral administration of a CXCR1/2 inhibitor, DF 2162, in ...

Investigação funcional de CXCR7 na hematopoese normal e leucêmicaCXCR7 functional investigation in normal and leukemic hematopoiesis

Melo, Rita de Cássia Carvalho, 1988- ([s.n.], 2016)

Dysregulation of stromal derived factor 1/CXCR4 axis in the megakaryocytic lineage in essential thrombocythemia

Salim, Juan Pablo; Goette, Nora Paula; Lev, Paola Roxana; Chazarreta, Carlos Daniel; Heller, Paula Graciela; Alvarez, Clarisa Ester; Molinas, Felisa Concepción; Marta, Rosana Fernanda (Wiley Blackwell Publishing, Inc, 2009-01)

This study investigated the involvement of chemokines including stromal derived factor 1 (SDF-1), interleukin 8 (IL-8), growth-related oncogene alpha (GRO-a) and their receptors, CXCR4, CXCR2 and CXCR1 in essential ...

Differential expression of SDF-1 receptor CXCR4 in molecularly defined forms of inherited thrombocytopenias

Salim, Juan Pablo; Glembotsky, Ana Claudia; Lev, Paola Roxana; Marin Oyarzún, Cecilia Paola; Goette, Nora Paula; Molinas, Felisa Concepción; Marta, Rosana Fernanda; Heller, Paula Graciela (Taylor & Francis Ltd, 2016-12)

The SDF-1-CXCR4 axis plays an essential role in the regulation of platelet production, by directing megakaryocyte (MK) migration toward the vascular niche, thus allowing terminal maturation and proplatelet formation, and ...

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