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Receptor-binding variants of H3N2 influenza A viruses: characterization of their sialidase activity towards different substrates
(Instituto de Ci??ncias da Sa??de/ Universidade Federal da Bahia, 2004-01)
Receptor-binding variants of H3N2 influenza A viruses: characterization of their sialidase activity towards different substrates
(Instituto de Ciências da Saúde/ Universidade Federal da Bahia, 2004)
Influenza virus sialidase develops an essential activity on cellular glycoproteins, then permitting the dissemination of the
virus infections by preventing virus-virus self aggregation and virus-cell rebinding. Two purified ...
Androgen receptor signaling in prostate cancer: Genetic and molecular aspects
(2014-01-01)
The prostate is an accessory sex gland of the male reproductive system, which produces alkaline prostatic fluid, capable of ensuring the spermatic viability to fertilize eggs within the female reproductive system. Functionally, ...
Evidence for two progesterone receptor binding sites in murine mammary carcinomas
(Pergamon-Elsevier Science Ltd., 2003-01)
We have evaluated the progesterone receptor (PR) binding patterns in progestin-dependent and -independent murine mammary carcinomas; all variants regress completely after antiprogestin treatment. These studies revealed the ...
Recent advances in SARS-CoV-2 Spike protein and RBD mutations comparison between new variants Alpha (B.1.1.7, United Kingdom), Beta (B.1.351, South Africa), Gamma (P.1, Brazil) and Delta (B.1.617.2, India)
(2021-09-01)
New variants of SARS-CoV-2 Alpha (B.1.1.7); Beta (B.1.351) Gamma (P.1) and Delta (B.1.617.2) quickly spread in the UK, South Africa, Brazil and India, respectively. To address whether mutations in SARS-CoV-2 RBD spike ...
Molecular Dynamics and MM-PBSA Analysis of the SARS-CoV-2 Gamma Variant in Complex with the hACE-2 Receptor
(MDPI, 2022)
The SARS-CoV-2 virus, since its appearance in 2019, has caused millions of cases and deaths. To date, there is no effective treatment or a vaccine that is fully protective. Despite the efforts made by governments and health ...
Ómicron SARS-CoV-2 variant: A new variant of concernVariante Ómicron SARS-CoV-2: Una nueva variante de preocupación
(Universidad de Valparaíso, 2021)
Molecular recognition and binding mechanism of N-alkyl- benzyltetrahydroisoquinolines to the D1 dopamine receptor. A computational approach
(Elsevier Science, 2003-12)
In order to better understand, at sub-molecular level, the minimal structural requirements for the recognition process in the inhibitory activity, a series of N-alkyl-benzyltethrahydroisoquinolines (BTHIQs) were examined ...
Glucocorticoid receptor quaternary structure drives chromatin occupancy and transcriptional outcome
(Cold Spring Harbor Laboratory Press, 2019-08)
Most transcription factors, including nuclear receptors, are widely modeled as binding regulatory elements as monomers, homodimers, or heterodimers. Recent findings in live cells show that the glucocorticoid receptor NR3C1 ...
Ligand dissociation from estrogen receptor is mediated by receptor dimerization: Evidence from molecular dynamics simulations
(ENDOCRINE SOC, 2008)
Estrogen Receptor (ER) is an important target for pharmaceutical design. Like other ligand-dependent transcription factors, hormone binding regulates ER transcriptional activity. Nevertheless, the mechanisms by which ligands ...