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TrkB and the calpain dependent-Tc TrkB receptor isoforms: possible neurological therapeutic targets
(Sciaccess Publishers, 2016-12)
Several neurological conditions share a characteristic feature: an increase in intracellular calcium levels ([Ca2+]i). It has been demonstrated that calcium
influx induces changes ranging from an increase in the expression ...
Tyrosine kinase A receptor (trkA): A potential marker in epithelial ovarian cancer
(Elsevier, 2011)
Objectives. To evaluate the role of trkA receptor as a potential tumor marker in serous epithelial ovarian
cancer and its relationship with the angiogenic factors expression as vascular endothelial growth factor
(VEGF) ...
TrkA glycosylation regulates receptor localization and activity
(Wiley-Blackwell, 1999-05-01)
The human nerve growth factor receptor (TrkA) contains four potential N-glycosylation sites that are highly conserved within the Trk family of neurotrophin receptors, and nine additional sites that are less well conserved. ...
An Agonistic mAb Directed to the TrkC Receptor Juxtamembrane Region Defines a Trophic Hot Spot and Interactions with p75 Coreceptors
(2010)
The D5 domain of TrkC receptors is a docking site for Neurotrophin-3 (NT-3), but other domains may be relevant for function or harmonizing signals with p75(NTR) coreceptors. We report a monoclonal antibody (mAb) 2B7 targeting ...
Antagonistic effects of TrkB and p75NTR on NMDA receptor currents in post-synaptic densities transplanted into Xenopus oocytes
(International Society for Neurochemistry, 2007)
Brain-derived neurotrophic factor (BDNF) and its receptor TrkB
are essential regulators of synaptic function in the adult CNS. A
TrkB-mediated effect at excitatory synapses is enhancement of
NMDA receptor (NMDA-R)-mediated ...
Loss of TrkB signaling due to status epilepticus induces a proBDNF-dependent cell death
(Frontiers Research Foundation, 2019-01-08)
Neurotrophins (NTs) are secretory proteins that bind to target receptors and influence many cellular functions, such as cell survival and cell death in neurons. The mammalian NT brain-derived neurotrophic factor (matBDNF) ...
Effect of GnRH analogs on the expression of TrkA and p75 neurotrophin receptors in primary cell cultures from human prostate adenocarcinoma
(WILEY-LISS, DIV JOHN WILEY & SONS INC, 2005-11-01)
BACKGROUND. GnRH analogs have antiproliferative and/or apoptotic effects on prostate cancer cells. Also, neurotrophin receptors TrkA and p75 have been reported in normal prostate suggesting a role in the gland growth ...
The paradoxical signals of two TrkC receptor isoforms supports a rationale for novel therapeutic strategies in ALS
(Public Library of Science, 2016-10)
Full length TrkC (TrkC-FL) is a receptor tyrosine kinase whose mRNA can be spliced to a truncated TrkC.T1 isoform lacking the kinase domain. Neurotrophin-3 (NT-3) activates TrkC-FL to maintain motor neuron health and ...
TrkB receptors are required for follicular growth and oocyte survival in the mammalian ovary (vol 267, pg 430, 2004)
(ACADEMIC PRESS INC ELSEVIER SCIENCE, 2004-06-01)
Although it is well established that both follicular assembly and the initiation of follicle growth in the mammalian ovary occur independently of pituitary hormone support, the factors controlling these processes remain ...