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PAR-1 and PAR-2 Expression Is Enhanced in Inflamed Odontoblast Cells
(2017-12-01)
Protease-activated receptors (PARs) are G protein–coupled receptors, which are activated by proteolytical cleavage of the amino-terminus and act as sensors for extracellular proteases. We hypothesized that PAR-1 and PAR-2 ...
Papel do Receptor Ativado por Protease (PAR)2 no recrutamento de neutrófilos induzido pelo Fator Ativador de Plaquetas (PAF)
(Universidade Federal de Minas GeraisBrasilICB - DEPARTAMENTO DE FARMACOLOGIAPrograma de Pós-Graduação em Ciências Biológicas - Fisiologia e FarmacologiaUFMG, 2021-09-10)
At the lung inflammation microenvironment containing platelet-activating factor (PAF), proteases and protease-activated receptor (PAR)2 are also abundantly present. Despite this evidence, a cooperation between PAF and ...
Avaliação bioquímica e molecular dos receptores ativados por proteases (PARs) em modelos de privação de sono
(Universidade Federal de São Paulo (UNIFESP), 2012)
A funcao do sono ainda nao foi completamente elucidada, porem se sabe que este tem papel homeostatico, e na sua privacao, ocorrem diversas alteracoes fisiologicas e patologicas, como no sistema imunologico e na reacao ...
EGF receptor transactivation by urokinase receptor stimulus through a mechanism involving Src and matrix metalloproteinases
(ACADEMIC PRESS INC ELSEVIER SCIENCE, 2004-01-01)
Urokinase-type plasminogen activator receptor (uPAR) and epidermal growth factor receptor (EGFR) are ubiquitous receptors involved in the control of a variety of cellular processes frequently found altered in cancer cells. ...
Proteinase-activated receptor-2 (PAR2) agonist causes periodontitis in rats
(2005-02-01)
Proteinase-activated receptor-2 (PAR2) is a G-protein-coupled receptor that mediates cellular responses to extracellular proteinases. Since PAR2 is expressed by oral epithelial cells, osteoblasts, and gingival fibroblasts, ...
Proteinase-activated receptor-2 (PAR2) agonist causes periodontitis in rats
(2005-02-01)
Proteinase-activated receptor-2 (PAR2) is a G-protein-coupled receptor that mediates cellular responses to extracellular proteinases. Since PAR2 is expressed by oral epithelial cells, osteoblasts, and gingival fibroblasts, ...
Estudo do papel dos receptores ativados por protease (PAR)2 E PAR4 na fagocitose e ativação in vitro de macrófagos peritoneais obtidos de camundongos C57BL/6
(Universidade Federal de Minas GeraisUFMG, 2015-11-27)
The protease activated receptors (PAR) belong to the family of G protein-coupled receptors and are targets of serine proteases, classified from 1 to 4 depending on the order of discovery. Both PAR2 and PAR4 are expressed ...
Protease-activated Receptor-2 (PAR(2)) in Human Periodontitis
(SAGE PUBLICATIONS INC, 2010)
No evidence for the role of protease-activated receptor-2 (PAR(2)) in human periodontal disease has been demonstrated so far. Thus, we sought to investigate the expression of PAR(2) mRNA in chronic periodontitis, and to ...