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Altered renal response to acute volume expansion in transgenic rats harboring the human tissue kallikrein gene
(Elsevier B.V., 2005-01-15)
The renal response to acute volume expansion was investigated in transgenic (TGR) rats harboring the human tissue kallikrein gene. After a printer injection of 0.9% NaCl (3 ml/100 g, i.v), Sprague-Dawley (SD) or TGR rats ...
Longitudinal analysis of the behavioral phenotype in a novel transgenic rat model of early stages of Alzheimer's disease
(Frontiers, 2014-09)
Intraneuronal accumulation of amyloid beta (iAbeta) has been linked to mild cognitive impairment that may precede Alzheimers disease (AD) onset. This neuropathological trait was recently mimicked in a novel animal model ...
Development and characterization of a new inbred transgenic rat strain expressing DsRed monomeric fluorescent protein
(Springer, 2014-10)
The inbred rat is a suitable model for studying human disease and because of its larger size is more amenable to complex surgical manipulation than the mouse. While the rodent fulfills many of the criteria for transplantation ...
Prevention of cardiac fibrosis and left ventricular dysfunction in diabetic cardiomyopathy in rats by transgenic expression of the human tissue kallikrein gene
(Federation Amer Soc Exp Biol, 2004-05-01)
Diabetic cardiomyopathy includes fibrosis. Kallikrein (KLK) can inhibit collagen synthesis and promote collagen breakdown. We investigated cardiac fibrosis and left ventricular (LV) function in transgenic rats (TGR) ...
Adult hippocampal neurogenesis impairment at preplaque stage in a transgenic rat model of Alzheimer like amyloid pathology
(Wiley Blackwell Publishing, Inc, 2019)
The contribution of adult hippocampal neurogenesis (AHN) impairment on cognitive decline in early Alzheimer disease (AD) remains poorly understood. This can be ascribed to the technical difficulties to measure AHN in ...
Histomorphology and ultrastructure of pancreatic islet tissue during in vivo maturation of rat pancreas
(Elsevier Gmbh, Urban & Fischer VerlagJenaAlemanha, 2006)
Platelets Bioenergetics Screening Reflects the Impact of Brain Aβ Plaque Accumulation in a Rat Model of Alzheimer
(Springer/Plenum Publishers, 2019-06)
Alzheimer’s disease (AD) is associated to depressed brain energy supply and impaired cortical and hippocampal synaptic function. It was previously reported in McGill-R-Thy1-APP transgenic (Tg(+/+)) rats that Aβ deposition ...