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Focal adhesion kinase - The basis of local hypertrophic signaling domains
(ElsevierLondon, 2012)
Aldose reductase induced by hyperosmotic stress mediates cardiomyocyte apoptosis - Differential effects of sorbitol and mannitol
(AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2003-10-03)
Cells adapt to hyperosmotic conditions by several mechanisms, including accumulation of sorbitol via induction of the polyol pathway. Failure to adapt to osmotic stress can result in apoptotic cell death. In the present ...
Regulation of intracellular pH is altered in cardiac myocytes of ovariectomized rats
(American Heart Association, Inc, 2019-04-02)
Background-—It is well known that after menopause women are exposed to a greater cardiovascular risk, but the intracellular modifications are not properly described. The sodium/proton exchanger (NHE) and the sodium/bicarbonate ...
Gender differences in cardiac left ventricular mass and function: clinical and experimental observations
(Via Medica, 2014-01)
Background: The aim of this study was to evaluate gender-associated impact on left ventricular mass (LVM) and on left ventricular function (LVF) in humans and rats with aging. Methods: Myocyte area and collagen volume ...
Ca2+/Calmodulin-Dependent Protein Kinase II and Androgen Signaling Pathways Modulate MEF2 Activity in Testosterone-Induced Cardiac Myocyte Hypertrophy
(2017)
Testosterone is known to induce cardiac hypertrophy through androgen receptor (AR)-dependent and -independent pathways, but the molecular underpinnings of the androgen action remain poorly understood. Previous work has ...