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Lack of association between BRAF mutation and MAPK ERK activation in melanocytic nevi
(NATURE PUBLISHING GROUP, 2006)
The mitogen-activated protein kinase (MAPK) extracellular signal-regulated kinase signaling pathway can be activated through mutations of V-RAF murine sarcoma viral oncogene homolog B1 (BRAF) oncogene, frequently found in ...
Raf Kinase Inhibitor Protein Expression and Prognostic Value in Soft Tissue Sarcomas
(2016-03-01)
Objective: Soft tissue sarcomas (STSs) are heterogeneous tumors displaying multiple and complex molecular abnormalities with no specific pattern. Despite current therapeutic advances, the patients with STS still have a ...
Proteomic analysis of low- to high-grade astrocytomas reveals an alteration of the expression level of raf kinase inhibitor protein and nucleophosmin
(WILEY-V C H VERLAG GMBH, 2010)
Proteomic approaches have been useful for the identification of aberrantly expressed proteins in complex diseases such as cancer. These proteins are not only potential disease biomarkers, but also targets for therapy. The ...
Activation of RAF-1 through Ras and Protein Kinase Cα Mediates 1α,25(OH)2-Vitamin D3 Regulation of the Mitogen-activated Protein Kinase Pathway in Muscle Cells
(American Society for Biochemistry and Molecular Biology, 2003-01-24)
We have previously shown that stimulation of proliferation of avian embryonic muscle cells (myoblasts) by 1α,25(OH)2-vitamin D3 (lα,25(OH)2D3) is mediated by activation of the mitogen-activated protein kinase (MAPK; ERK1/2). ...
Kinase-Impaired BRAF Mutations in Lung Cancer Confer Sensitivity to Dasatinib
(AMER ASSOC ADVANCEMENT SCIENCE, 2012)
During a clinical trial of the tyrosine kinase inhibitor dasatinib for advanced non-small cell lung cancer (NSCLC), one patient responded dramatically and remains cancer-free 4 years later. A comprehensive analysis of his ...
Endoplasmic reticulum stress-independent activation of unfolded protein response kinases by a small molecule ATP-mimic
(ELIFE SCIENCES PUBLICATIONS, 2015-05)
Two ER membrane-resident transmembrane kinases, IRE1 and PERK, function as stress sensors in the unfolded protein response. IRE1 also has an endoribonuclease activity, which initiates a non-conventional mRNA splicing ...
Insights into the Interactions between Maleimide Derivates and GSK3 beta Combining Molecular Docking and QSAR
(PUBLIC LIBRARY SCIENCE, 2014)
Epidermal growth factor receptor controls glycogen phosphorylase in T cells through small GTPases of the RAS family
(American Society for Biochemistry and Molecular Biology, 2019-03-22)
We recently uncovered a regulatory pathway of the muscle isoform of glycogen phosphorylase (PYGM) that plays an important role in regulating immune function in T cells. Here, using various enzymatic, pulldown, and ...