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Essential roles of zebrafish rtn4/Nogo paralogues in embryonic development
(BMC, 2014)
Background: As a consequence of gene/genome duplication, the RTN4/Nogo gene has two counterparts in zebrafish: rtn4a and rtn4b. The shared presence of four specific amino acid motifs—M1 to M4—in the N-terminal region of ...
Essential roles of zebrafish rtn4/Nogo paralogues in embryonic development
(BioMed Central, 2014)
Background: As a consequence of gene/genome duplication, the RTN4/Nogo gene has two counterparts in zebrafish: rtn4a and rtn4b. The shared presence of four specific amino acid motifs-M1 to M4-in the N-terminal region of ...
Focal CO2 dialysis in raphe obscurus does not stimulate ventilation but enhances the response to focal CO2 dialysis in the retrotrapezoid nucleus
(AMER PHYSIOLOGICAL SOC, 2008)
Simultaneous inhibition of the retrotrapezoid nucleus (RTN) and raphe obscurus (ROb) decreased the systemic CO2 response by 51%, an effect greater than inhibition of RTN (- 24%) or ROb (0%) alone, suggesting that ROb ...
Peripheral chemoreceptor inputs to retrotrapezoid nucleus (RTN) CO2-sensitive neurons in rats
(Blackwell Publishing, 2006-04-15)
The rat retrotrapezoid nucleus (RTN) contains pH-sensitive neurons that are putative central chemoreceptors. Here, we examined whether these neurons respond to peripheral chemoreceptor stimulation and whether the input is ...
Geração de expiração ativa : mecanismos centrais e implicações nas alterações cardiorrespiratórias associadas à hipóxia intermitente
(Universidade Federal de São CarlosUFSCarPrograma Interinstitucional de Pós-Graduação em Ciências Fisiológicas - PIPGCFCâmpus São Carlos, 2016-08-05)
The exposure to periods of hypoxemia and reoxygenation, as observed in patients with
obstructive sleep apnea (OSA), promotes compensatory increases in ventilation, sympathetic activity and blood pressure (BP), by mechanisms ...
Serotonergic neurons activate chemosensitive retrotrapezoid nucleus neurons by a pH-independent mechanism
(Soc Neuroscience, 2007-12-19)
Serotonin activates respiration and enhances the stimulatory effect of CO2 on breathing. the present study tests whether the mechanism involves the retrotrapezoid nucleus (RTN), a group of medullary glutamatergic neurons ...
Activation of 5-hydroxytryptamine type 3 receptor-expressing c-fiber vagal afferents inhibits retrotrapezoid nucleus chemoreceptors in rats
(Amer Physiological Soc, 2007-12-01)
Retrotrapezoid nucleus (RTN) chemoreceptors are regulated by inputs from the carotid bodies (CB) and from pulmonary mechanoreceptors. Here we tested whether RTN neurons are influenced by 5-hydroxytryptamine type 3 ...
Effects of leptin in the retrotrapezoid nucleus (RTN) on CO2-sensitivity and respiration
(Federation Amer Soc Exp Biol, 2013-04-01)
Inhibitory input from slowly adapting lung stretch receptors to retrotrapezoid nucleus chemoreceptors
(Blackwell Publishing, 2007-04-01)
The retrotrapezoid nucleus (RTN) contains CO2-activated interneurons with properties consistent with central respiratory chemoreceptors. These neurons are glutamatergic and express the transcription factor Phox2b. Here we ...
Contribution of retrotrapezoid/parafacial respiratory region to the expiratory-sympathetic coupling in response to peripheral chemoreflex in rats
(2012)
Central mechanisms of coupling between respiratory and sympathetic systems are essential for the entrainment between the enhanced respiratory drive and sympathoexcitation in response to hypoxia. However, the brainstem ...