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Comparative effects of transforming growth factor beta isoforms on redox metabolism in thyroid cells
(Elsevier Ireland, 2017-10)
Introduction: Transforming growth factor beta (TGF-β) regulates thyroid function and growth. However, tumoral thyroid cells became resistant to this factor as they undifferentiated. Little is known about the effects of ...
Reproduction and oxidative metabolism in the brooding sea star Anasterias antarctica (Lütken, 1957)
(Elsevier, 2015-01)
The oral-brooding sea star Anasterias antarctica is distributed on the coasts of South Patagonia and north of Antarctic Peninsula. This species is a potential predator of shellfish Mytilus chilensis, an important commercial ...
Regulation of tolerogenic features on dexamethasone-modulated MPLA-activated dendritic cells by Myc
(Frontiers Media S.A., 2019)
Copyright © 2019 García-González, Maggi, Schinnerling, Sepúlveda-Gutiérrez, Soto, Neira, Mehdi, Nel, Pesce, Aravena, Molina, Catalán, Thomas, Verdugo and Aguillón.The potential of tolerogenic dendritic cells (tolDCs) to ...
An exacerbated metabolism and mitochondrial reactive oxygen species contribute to mitochondrial alterations and apoptosis in CD4 T cells during the acute phase of Trypanosoma cruzi infection
(Elsevier Science Inc., 2021-02-01)
Chagas disease caused by Trypanosoma cruzi parasite is an endemic infection in America. It is well known that T. cruzi causes a strong immunosuppression during the acute phase of infection. However, it is not clear whether ...
Frataxin deficiency in neonatal rat ventricular myocytes targets mitochondria and lipid metabolism
(Elsevier, 2014-08)
Friedreich ataxia (FRDA) is a hereditary disease caused by deficient frataxin expression. This mitochondrial protein has been related to iron homeostasis, energy metabolism, and oxidative stress. Patients with FRDA experience ...
Integrating mitochondrial energetics, Redox and ROS metabolic networks: a two-compartment model
(Elsevier, 2013-01)
To understand the mechanisms involved in the control and regulation of mitochondrial reactive oxygen species (ROS) levels, a two-compartment computational mitochondrial energetic-redox (ME-R) model accounting for energetic, ...
Metabolic syndrome and male fertility disorders: Is there a causal link?
(Springer, 2021-05)
Infertility is a global health problem affecting 10–15% of couples in reproductive age. Recent studies have provided growing evidence supporting that lifestyle factors can affect male fertility through alterations in ...
Mitochondrial Reactive Oxygen Species (ROS) and Arrhythmias.
(Springer Verlag Berlín, 2014)
In this chapter we analyze the onset of cardiac arrhythmias from the perspective of mitochondrial redox state and energetic metabolism. Significant perturbations in the mitochondrial redox environment trigger mitochondrial ...
Redox metabolism in Trypanosoma cruzi: functional characterization of tryparedoxins revisited
(Elsevier, 2013-10)
Tryparedoxins (TXNs) are multipurpose oxidoreductases from trypanosomatids that transfer reducing equivalents from trypanothione to different thiol proteins. In Trypanosoma cruzi, two genes coding for TXN like proteins ...