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Assessment of external guide sequences' (EGS) efficiency as inducers of RNase P-mediated cleavage of mRNA target molecules
(Humana Press, 2018)
RNase P is a ribozyme consisting of a catalytic RNA molecule and, depending on the organism, one or more cofactor proteins. It was initially identified as the enzyme that mediates cleavage of precursor tRNAs at the 5´-end ...
Targeting HIV-1 integrase with aptamers selected against the purified RNase H domain of HIV-1 RT
(ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER, 2005-10)
Several in vitro strategies have been developed to selectively screen for nucleic acid sequences that bind to specific proteins. We previously used the SELEX procedure to search for aptamers against HIV-1 RNase H activity ...
The 20S proteasome alpha(5) subunit of Arabidopsis thaliana carries an RNase activity and interacts in planta with the Lettuce mosaic potyvirus HcPro protein
(Wiley-Blackwell, 2011-02-01)
P>In plants, the ubiquitin/26S proteasome system (UPS) plays a central role in protein degradation and is involved in many steps of defence mechanisms, regardless of the types of pathogen targeted. In addition to its ...
Identification of the acinetobacter baumannii ribonuclease p catalytic subunit: Cleavage of a target mRNA in the presence of an external guide sequence
(Frontiers Research Foundation, 2018-10)
The bacterial ribonuclease P or RNase P holoenzyme is usually composed of a catalytic RNA subunit, M1, and a cofactor protein, C5. This enzyme was first identified for its role in maturation of tRNAs by endonucleolytic ...
Aminoglycoside modifying enzymes
(Churchill Livingstone, 2010-09)
Aminoglycosides have been an essential component of the armamentarium in the treatment of life-threatening infections. Unfortunately, their efficacy has been reduced by the surge and dissemination of resistance. In some ...
The 20S proteasome alpha(5) subunit of Arabidopsis thaliana carries an RNase activity and interacts in planta with the Lettuce mosaic potyvirus HcPro protein
(Wiley-Blackwell, 2011-02-01)
P>In plants, the ubiquitin/26S proteasome system (UPS) plays a central role in protein degradation and is involved in many steps of defence mechanisms, regardless of the types of pathogen targeted. In addition to its ...
Ribonuclease production by Aspergillus species
(Soc Brasileira Microbiologia, 1998-07-01)
Ribonuclease production by Aspergillus flavipes. A sulphureus and A. fischeri in semisynthetic medium, after 24-144 hours at 30 degrees C under shaking, was studied. After cultivation, the medium was separated from micelia ...
Prevalência de resistência primária em pacientes HIV-1 positivos com diferentes subtipos virais no extremo sul do Brasil 2005-2008
(Universidade Federal de Minas GeraisUFMG, 2010-12-13)
Brazil has a program which is a model in the prevention, diagnosis and treatment of HIV-1 infections. Besides, the regional monitoring of molecular epistemology and transmitted drug resistance (TDR) are essential. The ...