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Alternative splicing and transcription elongation in plants
(Frontiers Media S.A., 2019-03)
Alternative splicing and transcription elongation by RNA polymerase II (RNAPII) are two processes which are tightly connected. Splicing is a co-transcriptional process, and different experimental approaches show that ...
Transcription directed by human core promoters with a HomolD box sequence requires DDB1, RECQL and RNA polymerase II machinery
(2012)
TATA box is the most studied core promoter element and has a well-described transcription mechanism. However, most metazoan promoters lack TATA box and contain other core promoter elements. One of such elements is HomolD ...
La respuesta transcripcional y de splicing alternativo al daño al ADN y el rol de la glucógeno sintasa kinasa 3 (GSK-3)The transcriptional and alternative splicing response to DNA damage and the role of glycogen synthase kinase 3 (GSK-3)
(2019-03-25)
En esta tesis doctoral estudiamos la respuesta transcripcional y de splicing alternativo (SA) al daño al ADN producido por luz ultravioleta (UV) en células humanas en cultivo. Los CPDs, lesiones en el ADN producidas por ...
Estudio de los factores involucrados en el modelamiento nucleosomal que permiten o facilitan la transcripción por rnapii, en moldes de dna ensamblados como nucleosomas, en schizosaccharomyces pombe
(2013)
La familia de remodeladores de la cromatina dependientes de ATP, juega unpapel central en la regulación de la transcripción en eucariontes. Estos complejos alteran la estructura de la cromatina mediante mecanismos que ...
How Are Short Exons Flanked by Long Introns Defined and Committed to Splicing?
(Elsevier Science London, 2016-10)
The splice sites (SSs) delimiting an intron are brought together in the earliest step of spliceosome assembly yet it remains obscure how SS pairing occurs, especially when introns are thousands of nucleotides long. Splicing ...
A slow transcription rate causes embryonic lethality and perturbs kinetic coupling of neuronal genes
(Nature Publishing Group, 2019-04)
The rate of RNA polymerase II (RNAPII) elongation has an important role in the control of alternative splicing (AS); however, the in vivo consequences of an altered elongation rate are unknown. Here, we generated mouse ...
Enzymatic Protein Biopolymers as a Tool to Synthetize Eukaryotic Messenger Ribonucleic Acid (mRNA) with Uses in Vaccination, Immunotherapy and Nanotechnology
(MDPI, 2020)
: Multi-subunit enzymes are protein biopolymers that are involved in many cellular processes.
The enzyme that carries out the process of transcription of mRNAs is RNA polymerase II (RNAPII),
which is a multi-subunit ...
RNA polymerase II components and Rrn7 form a preinitiation complex on the HomolD box to promote ribosomal protein gene expression in Schizosaccharomyces pombe
(Blackwell Publishing Ltd, 2017)
© 2017 Federation of European Biochemical Societies In Schizosaccharomyces pombe, ribosomal protein gene (RPG) promoters contain a TATA box analog, the HomolD box, which is bound by the Rrn7 protein. Despite the importance ...
Enzymatic protein biopolymers as a tool to synthetize eukaryotic messenger Ribonucleic Acid (mRNA) with uses in vaccination, immunotherapy and nanotechnology
(MDPI, 2020)
Multi-subunit enzymes are protein biopolymers that are involved in many cellular processes. The enzyme that carries out the process of transcription of mRNAs is RNA polymerase II (RNAPII), which is a multi-subunit enzyme ...