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Footprints of a trypanosomatid RNA world: pre-small subunit rRNA processing by spliced leader addition trans-splicing
(FUNDACO OSWALDO CRUZRIO DE JANEIRO, 2013-08-02)
The addition of a capped mini-exon [spliced leader (SL)] through trans-splicing is essential for the maturation of RNA polymerase (pol) II-transcribed polycistronic pre-mRNAs in all members of the Trypanosomatidae family. ...
CaMKIId Splice variants in the healthy and diseased heart
(Frontiers Media, 2021)
RNA splicing has been recognized in recent years as a pivotal player in heart
development and disease. The Ca2C/calmodulin dependent protein kinase II delta
(CaMKIId) is a multifunctional Ser/Thr kinase family and generates ...
Detection of human interchromosomal trans-splicing in sequence databanks
(Oxford Univ PressOxfordInglaterra, 2010)
Identification of SL addition trans-splicing acceptor sites in the internal transcribed spacer I region of pre-rRNA in Leishmania (Leishmania) amazonensis
(Instituto Oswaldo Cruz, Ministério da Saúde, 2012)
Trypanosomatidae is a family of early branching eukaryotes harbouring a distinctive repertoire of gene expression strategies. Functional mature messenger RNA is generated via the trans-splicing and polyadenylation processing ...
Trans-splicing correction of tau isoform imbalance in a mouse model of tau mis-splicing
(Oxford University Press, 2013-07)
Abnormal metabolism of the tau protein is central to the pathogenesis of a number of dementias, including Alzheimer's disease. Aberrant alternative splicing of exon 10 in the tau pre-mRNA resulting in an imbalance of tau ...
Proteomics uncovers novel components of na interactive protein network supporting RNA export in trypanosomes
(American Society for Biochemistry and Molecular Biology / Elsevier, 2022)
Alternative splicing switches: Important players in cell differentiation
(John Wiley & Sons Inc, 2017-06-27)
Alternative splicing (AS) greatly expands the coding capacities of genomes by allowing the generation of multiple mature mRNAs from a limited number of genes. Although the massive switch in AS profiles that often accompanies ...