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c-Abl activates RIPK3 signaling in Gaucher disease
(2021)
Gaucher disease (GD) is caused by homozygous mutations in the GBA1 gene, which encodes the lysosomal β-glucosidase (GBA) enzyme. GD affects several organs and tissues, including the brain in certain variants of the disease. ...
c-Abl activates RIPK3 signaling in Gaucher disease
(2021)
Gaucher disease (GD) is caused by homozygous mutations in the GBA1 gene, which encodes the lysosomal β-glucosidase (GBA) enzyme. GD affects several organs and tissues, including the brain in certain variants of the disease. ...
Programmed necrosis in the cross talk of cell death and inflammation
(Annual Reviews, 2015)
RIPK1-RIPK3-MLKL-Associated Necroptosis Drives Leishmania infantum Killing in Neutrophils
(Frontiers Media, 2018)
Leishmania braziliensis Subverts Necroptosis by Modulating RIPK3 Expression
(Frontiers Media, 2018)
c-Abl activates RIPK3 signaling in Gaucher disease
(2021-05-01)
Gaucher disease (GD) is caused by homozygous mutations in the GBA1 gene, which encodes the lysosomal β-glucosidase (GBA) enzyme. GD affects several organs and tissues, including the brain in certain variants of the disease. ...
Serine 25 phosphorylation inhibits RIPK1 kinase-dependent cell death in models of infection and inflammation
(NATURE PUBLISHING GROUP, 2019)
RIPK1 regulates cell death and inflammation through kinase-dependent and -independent mechanisms. As a scaffold, RIPK1 inhibits caspase-8-dependent apoptosis and RIPK3/MLKL-dependent necroptosis. As a kinase, RIPK1 ...
RIPK1-RIPK3-MLKL-Associated Necroptosis Drives Leishmania infantum Killing in Neutrophils
(Frontiers Media, 2018)
The diverse roles of RIP kinases in host-pathogen interactions
Receptor Interacting Protein Kinases (RIPKs) are cellular signaling molecules that are critical for homeostatic
signaling in both communicable and non-communicable disease processes. In particular, RIPK1, RIPK2, RIPK3
and ...