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The Conserved Tyr176/Leu177 motif in the alpha-Helix 9 of the feline immunodeficiency virus capsid protein is critical for gag particle assembly
(Multidisciplinary Digital Publishing Institute, 2019-09-04)
The capsid domain (CA) of the lentiviral Gag polyproteins has two distinct roles during virion morphogenesis. As a domain of Gag, it mediates the Gag–Gag interactions that drive immature particle assembly, whereas as a ...
ESTUDIO DE MUTAGÉNESIS INSERCIONAL DEL RETROVIRUS MMTV/HMTV EN MUESTRAS DE ADENOCARCINOMAS MAMARIOS DE MUJERES MEXICANAS
(2011-06-22)
In Mexico from 2006 breast cancer is the leading cause of death from malignancy in women, incidence data are reported at 38 per 100,000 habitants. Have identified most of the risk factors, however, the etiology is unknown. ...
Role of the 207-218 peptide region of Moloney murine leukemia virus integrase in enzyme catalysis
(2010)
X-ray diffraction data on a few retroviral integrases show a flexible loop near the active site. By sequence alignment, the peptide region 207-218 of Mo-MLV IN appears to correspond to this flexible loop. In this study, ...
Búsqueda de inhibidores de la multimerización de la proteína de la cápside del virus de inmunodeficiencia humana
(Udelar. FM, 2021)
El Virus de la Inmunodeficiencia Humana (VIH) es un retrovirus perteneciente a la subfamilia de los lentivirus. Es un virus ARN con la capacidad de regular su replicación dentro de la célula del hospedero. Su estructura ...
Understanding the process of envelope glycoprotein incorporation into virions in simian and feline immunodeficiency viruses
(MDPI, 2014-01)
The lentiviral envelope glycoproteins (Env) mediate virus entry by interacting with specific receptors present at the cell surface, thereby determining viral tropism and pathogenesis. Therefore, Env incorporation into the ...
Understanding the Process ofEnvelope Glycoprotein Incorporation into Virions in Simian and Feline Immunodeficiency Viruses
(Universidad de Belgrano - Facultad de Ciencias Exactas y Naturales - Proyectos de Investigación, 2014)
The lentiviral envelope glycoproteins (Env) mediate virus entry by interacting
with specific receptors present at the cell surface, thereby determining viral tropism and
pathogenesis. Therefore, Env incorporation into ...
DETECTION OF THE PEPTIDE P17-1 (HIV) BY SURFACE ENHANCE RAMAN SCATTERING (SERS)
(Soc Brasileira Quimica, 2019-01-01)
A bioanalytical method for HIV detection based on surface-enhanced Raman scattering (SERS) is described. The assay targeted the peptide p17-1. This peptide sequence is present in the protein p17, a structural protein ...
Mapping of the Self-Interaction Domains in the Simian Immunodeficiency Virus Gag Polyprotein
(Universidad de Belgrano - Facultad de Ciencias Exactas y Naturales - Proyectos de Investigación, 2011)
To gain a better understanding of the assembly process in simian immunodeficiency virus (SIV), we first established the conditions under which recombinant SIV Gag lacking the C-terminal p6 domain (SIV GagΔp6) assembled in ...
Silencing of HTLV-1 gag and env genes by small interfering RNAs in HEK 293 cells
(ELSEVIER SCIENCE BV, 2011)
Since the discovery of RNAi technology, several functional genomic and disease therapy studies have been conducted using this technique in the field of oncology and virology. RNAi-based antiviral therapies are being studied ...