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Mitochondrial Supercomplexes: Physiological Organization and Dysregulation in Age-Related Neurodegenerative Disorders
(Frontiers Media S.A., 2020-09)
Several studies suggest that the assembly of mitochondrial respiratory complexes into structures known as supercomplexes (SCs) may increase the efficiency of the electron transport chain, reducing the rate of production ...
Mitochondrial genotype modulates mtDNA copy number and organismal phenotype in Drosophila
(Elsevier B.V., 2017-05-01)
We evaluated the role of natural mitochondrial DNA (mtDNA) variation on mtDNA copy number, biochemical features and life history traits in Drosophila cybrid strains. We demonstrate the effects of both coding region and ...
Mitochondrial cytochrome c oxidase biogenesis: Recent developments
(Academic Press Ltd - Elsevier Science Ltd, 2018-04)
Mitochondrial cytochrome c oxidase (COX) is the primary site of cellular oxygen consumption and is essential for aerobic energy generation in the form of ATP. Human COX is a copper-heme A hetero-multimeric complex formed ...
Cyclophilin D over-expression increases mitochondrial complex III activity and accelerates supercomplex formation
(Elsevier Science Inc, 2017-01)
Cyclophilin D (CyPD), a mitochondrial matrix protein, has been widely studied for its role in mitochondrial-mediated cell death. Unexpectedly, we previously discovered that overexpression of CyPD in a stable cell line, ...
Cytochrome c, a hub linking energy, redox, stress and signalling pathways in mitochondria and other cell compartments
(Wiley Blackwell Publishing, Inc, 2016-04)
Cytochrome c (CYTc) is a soluble redox-active heme protein that transfers electrons from Complex III to Complex IV in the cyanide-sensitive mitochondrial respiratory pathway. CYTc biogenesis is a complex process that ...
D-lactate dehydrogenase links methylglyoxal degradation and electron transport through cytochrome
(American Society of Plant Biologist, 2016-10)
Glycolysis generates methylglyoxal (MGO) as an unavoidable, cytotoxic by-product in plant cells. MGO scavenging is performed by the glyoxalase system, which produces D-lactate as an end product. D-Lactate dehydrogenase ...
Brain mitochondria bioenergetics, nitrergic and neurotensinergic systems
(Nova Science Publishers, 2020)
Mitochondria display a central role in cellular activity, being essential for energetic metabolism, Ca2+ homeostasis and cell signalling. The brain is one of the organs with the highest oxygen consumption of the human body, ...