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Fasciola hepatica: Histological changes in the somatic and reproductive tissues of liver fluke following closantel treatment of experimentally-infected sheep
(Elsevier Science, 2016-01)
Lambs infected with the Cullompton isolate of Fasciola hepatica were treated orally or subcutaneously with 10 mg/kg of closantel at 16 weeks post-infection. Adult flukes were recovered from the liver of individual animals ...
Resistance induced changes on triclabendazole transport in Fasciola hepatica: ivermectin reversal effect
(American Society of Parasitologists, 2006-12)
Triclabendazole (TCBZ) and albendazole (ABZ) are flukicidal benzimidazole compounds extensively used in veterinary medicine. Although TCBZ has excellent activity against mature and immature stages of the liver fluke, ...
Albendazole enantiomeric metabolism and binding to cytosolic proteins in the liver fluke Fasciola hepatica
(Springer, 2008-08)
Fascioliasis causes important economic losses in ruminant species all over the world. Its control is largely based on the use of the flukicidal compound triclabendazole (TCBZ). However, its chemically related benzimidazole ...
Potentiation of triclabendazole action in vivo against a triclabendazole-resistant isolate of Fasciola hepatica following its co-administration with the metabolic inhibitor, ketoconazole
(Elsevier Science, 2012-02)
An in vivo study in the laboratory rat model has been carried out to monitor morphological changes in adult Fasciola hepatica over a 4-day period resulting from co-treatment with triclabendazole (TCBZ) and ketoconazole ...
Effect of the metabolic inhibitor, methimazole on the drug susceptibility of a triclabendazole-resistant isolate of Fasciola hepatica
(Cambridge University Press, 2009-02)
A study has been carried out to investigate whether the action of triclabendazole (TCBZ) is altered in the presence of a metabolic inhibitor. The flavin monooxygenase system (FMO) was inhibited using methimazole (MTZ) to ...
A murine model to assess anthelmintic resistance in Fasciola hepatica: Preliminary study
(Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica, 2019)
Fasciola hepatica (Fh) infection produce important loss in livestock industry, and is also an increasing concern for human public health1 . Additionally, the spread of anthelmintic resistance (AR) lead to treatments failure2 ...
Adaptive radiation of the flukes of the family fasciolidae inferred from genome-wide comparisons of key species
(Society for Molecular Biology and Evolution, 2020)
Liver and intestinal flukes of the family Fasciolidae cause zoonotic food–borne infections that impact both agriculture and human health throughout the world. Their evolutionary history and the genetic basis underlying ...
Testing albendazole resistance in Fasciola hepatica: validation of an egg hatch test with isolates from South America and the United Kingdom
(Cambridge University Press, 2013-03)
The main goal of the current work was to develop and validate an in vitro fluke egg hatch test, as a method for the detection of albendazole (ABZ) resistance in the liver fluke, Fasciola hepatica. Fluke eggs (200/ml, n ...
Characterization of a new albendazole resistant Fasciola hepatica isolate
(World Association for the Advancement of Veterinary Parasitology, 2021)
Characterization of a new albendazole resistant Fasciola hepatica isolateMaría Martínez-Valladares11,2, Elora Valderas-García1,2, Verónica Castilla Gómez de Agüero1,2, Marta González-Warleta3, Laura Ceballos4, Juan P. ...