Protein structure is not static; residues undergo conformational rearrangements and, in doing so, create, stabilize or break non-covalent interactions. Molecular dynamics (MD) is a technique used to simulate these movements ...

According to the generalized conformational selection model, ligand binding involves the co-existence of at least two conformers with different ligand-affinities in a dynamical equilibrium. Conformational transitions between ...

Protein-ligand interaction (PLI) networks show how proteins interact with small nonprotein ligands and can be used to study molecular recognition, which plays an important role in biological systems. The binding and ...

Aim: Investigating whether wild fish accept residual ration from cage fish farming to the point of changing their diet and the fish-food interaction network. Methods: The diet of fish species, Astyanax lacustris, Iheringichthys ...

Motivic pattern classification from music audio recordings is a challenging task. More so in the case of a cappella flamenco cantes, characterized by complex melodic variations, pitch instability, timbre changes, extreme ...

Recently, we have witnessed Deep Learning methodologies gaining significant attention for severity-based classification of dysarthric speech. Detecting dysarthria, quantifying its severity, are of paramount importance in ...

Amino acids committed to a particular function correlate tightly along evolution and tend to form clusters in the 3D structure of the protein. Consequently, a protein can be seen as a network of co-evolving clusters of ...

Protein-protein interactions (PPIs) mediate a variety of cellular processes and form complex networks, where connectivity is achieved owing to the “hub” proteins whose interaction with multiple protein partners is facilitated ...