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Oral immunization with recombinant Lactococcus lactis confers protection against respiratory pneumococcal infection
(National Research Council Canada-NRC Research Press, 2008-10-25)
In the present work, we evaluated if oral immunization with the pneumococcal protective protein A (PppA), expressed in the cell wall of Lactococcus lactis (L. lactis PppA+), was able to confer protective immunity against ...
Nasal immunization with Lactococcus lactis expressing the pneumococcal protective protein A induces protective immunity in mice
(American Society for Microbiology, 2008-06)
Nisin-controlled gene expression was used to develop a recombinant strain of Lactococcus lactis that is able to express the pneumococcal protective protein A (PppA) on its surface. Immunodetection assays confirmed that ...
Resistance of Young Mice to Pneumococcal Infection can be Improved by Oral Vaccination with Recombinant Lactococcus lactis
(Elsevier, 2010-02)
Background/Purpose: Oral immunization with Lactococcus lactis PppA (LPA+), a recombinant strain that is able to express the pneumococcal protective protein A, can improve the resistance to respiratory challenge with ...