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Cell-surface translational dynamics of nicotinic acetylcholine receptors
(Frontiers Research Foundation, 2014-11)
Synapse efficacy heavily relies on the number of neurotransmitter receptors available at a given time. In addition to the equilibrium between the biosynthetic production, exocytic delivery and recycling of receptors on the ...
Antibody-induced crosslinking and cholesterol-sensitive, anomalous diffusion of nicotinic acetylcholine receptors
(Wiley Blackwell Publishing, Inc, 2020-03)
Synaptic strength depends on the number of cell-surface neurotransmitter receptors in dynamic equilibrium with intracellular pools. Dysregulation of this homeostatic balance occurs, for example in myasthenia gravis, an ...
GibbsCluster: unsupervised clustering and alignment of peptide sequences
(Oxford University Press, 2017-04)
Receptor interactions with short linear peptide fragments (ligands) are at the base of many biological signaling processes. Conserved and information-rich amino acid patterns, commonly called sequence motifs, shape and ...
Frizzled-9 impairs acetylcholine receptor clustering in skeletal muscle cells.
(2014)
Cumulative evidence indicates that Wnt pathways play crucial and diverse roles to assemble the neuromuscular junction (NMJ), a peripheral synapse characterized by the clustering of acetylcholine receptors (AChR) on ...
Frizzled-9 impairs acetylcholine receptor clustering in skeletal muscle cells.
(2014)
Cumulative evidence indicates that Wnt pathways play crucial and diverse roles to assemble the neuromuscular junction (NMJ), a peripheral synapse characterized by the clustering of acetylcholine receptors (AChR) on ...
Cell-surface translational dynamics of nicotinic acetylcholine receptors
(Frontiers, 2014)
Abstract: Synapse efficacy heavily relies on the number of neurotransmitter receptors available at a given time. In addition to the equilibrium between the biosynthetic production, exocytic delivery and recycling of receptors ...
Improved pan-specific prediction of MHC class I peptide binding using a novel receptor clustering data partitioning strategy
(Wiley Blackwell Publishing, Inc, 2016-12)
Pan-specific prediction of receptor–ligand interaction is conventionally done using machine-learning methods that integrates information about both receptor and ligand primary sequences. To achieve optimal performance using ...
Antibody-induced acetylcholine receptor clusters inhabit liquid-ordered and liquid-disordered domains
(Elsevier, 2013-10)
The distribution of nicotinic acetylcholine receptor (AChR) clusters at the cell membrane was studied in CHO-K1/A5 cells using fluorescence microscopy. Di-4-ANEPPDHQ, a fluorescent probe that differentiates between ...
Antibody-induced acetylcholine receptor clusters inhabit liquid-ordered and liquid-disordered domains
(Elsevier B.V., 2013)
Abstract: The distribution of nicotinic acetylcholine receptor (AChR) clusters at the cell membrane was studied in CHO-K1/A5 cells using fluorescence microscopy. Di-4-ANEPPDHQ, a fluorescent probe that differentiates between ...
Propranolol restricts the mobility of single egf-receptors on the cell surface before their internalization
(PUBLIC LIBRARY SCIENCE, 2013)
The epidermal growth factor receptor is involved in morphogenesis, proliferation and cell migration. Its up-regulation during tumorigenesis makes this receptor an interesting therapeutic target. In the absence of the ligand, ...