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The long non-coding RNA ANRASSF1 in the regulation of alternative protein-coding transcripts RASSF1A and RASSF1C in human breast cancer cells: implications to epigenetic therapy
(2019-08-03)
Alternative protein-coding transcripts of the RASSF1 gene have been associated with dual functions in human cancer: while RASSF1C isoform has oncogenic properties, RASSF1A is a tumour suppressor frequently silenced by ...
Could dysregulation of RASSF1 expression be a mechanism of tumorigenesis in CTVT?
(Revista Pesquisa Veterinaria Brasileira, 2022-01-01)
Canine transmissible venereal tumor (CTVT) is the oldest known somatic cell lineage. It is a transmissible cancer that propagates naturally in dogs and reportedly contains gene mutations. RASSF1 participates in DNA damage ...
Evidence of epigenetic regulation of the tumor suppressor gene cluster flanking RASSF1 in breast cancer cell lines
(Landes Bioscience, 2011-12-01)
Epigenetic mechanisms are frequently deregulated in cancer cells and can lead to the silencing of genes with tumor suppressor activities. The isoform A of the Ras-association domain family member 1 (RASSF1A) gene is one ...
Evidence of epigenetic regulation of the tumor suppressor gene cluster flanking RASSF1 in breast cancer cell lines
(Landes Bioscience, 2011-12-01)
Epigenetic mechanisms are frequently deregulated in cancer cells and can lead to the silencing of genes with tumor suppressor activities. The isoform A of the Ras-association domain family member 1 (RASSF1A) gene is one ...
Alterações epigenéticas do gene RASSF1 e investigação de modulação gene-específica por non-coding RNA em linhagens celulares derivadas de carcinomas mamários
(Universidade Estadual Paulista (UNESP), 2015)
Alterações epigenéticas do gene RASSF1 e investigação de modulação gene-específica por non-coding RNA em linhagens celulares derivadas de carcinomas mamários
(Universidade Estadual Paulista (Unesp), 2015)
The intronic long noncoding RNA ANRASSF1 recruits PRC2 to the RASSF1A promoter, reducing the expression of RASSF1A and increasing cell proliferation
(Public Library of ScienceSan Francisco, 2013)
The down-regulation of the tumor-suppressor gene RASSF1A has been shown to increase cell proliferation in several tumors. RASSF1A expression is regulated through epigenetic events involving the polycomb repressive complex ...
Alterações epigenéticas do gene RASSF1 e investigação de modulação gene-específica por non-coding RNA em linhagens celulares derivadas de carcinomas mamários
(Universidade Estadual Paulista (Unesp), 2014-10-09)
Alterações epigenéticas, incluindo as alterações da metilação do DNA, das modificações de histonas e da atividade de RNAs não codificadores, são eventos frequentes em células tumorais e estão associados às mudanças da ...
RASSF1A MUTATION IN MYELODYSPLASTIC SYNDROMES
(Elsevier B.V., 2017-04-01)