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Multiple giant cell lesions in patients with Noonan syndrome and cardio-facio-cutaneous syndrome
(Nature Publishing Group, 2009-04-01)
Noonan syndrome (NS) and cardio-facio-cutaneous syndrome (CFCS) are related developmental disorders caused by mutations in genes encoding various components of the RAS-MAPK signaling cascade. NS is associated with mutations ...
Análise da expressão das proteínas KRAS, BRAF e MEK da via de sinalização intracelular mitogen activated protein kinases (MAPK) no carcinoma hepatocelular associado a hepatopatia crônica de diferentes etiologias
(Universidade Federal de Minas GeraisBrasilMEDICINA - FACULDADE DE MEDICINAPrograma de Pós-Graduação em Ciências Aplicadas à Saúde do AdultoUFMG, 2018-08-10)
Introduction: hepatocellular carcinoma (HCC), a very aggressive cancer, common in adults, can be initiated by factors like infection with hepatitis B virus (HBV) and regeneration of the liver induced by chronic diseases. ...
Regulation of Schistosoma mansoni Development and Reproduction by the Mitogen-Activated Protein Kinase Signaling Pathway
(Public Library of Science, 2015)
Activation of RAF-1 through Ras and Protein Kinase Cα Mediates 1α,25(OH)2-Vitamin D3 Regulation of the Mitogen-activated Protein Kinase Pathway in Muscle Cells
(American Society for Biochemistry and Molecular Biology, 2003-01-24)
We have previously shown that stimulation of proliferation of avian embryonic muscle cells (myoblasts) by 1α,25(OH)2-vitamin D3 (lα,25(OH)2D3) is mediated by activation of the mitogen-activated protein kinase (MAPK; ERK1/2). ...
New insights into the control of neurotrophic growth factor receptor signaling: Implications for nervous system development and repair
(Wiley Blackwell Publishing, Inc, 2012-12)
Neurotrophic growth factors control neuronal development by activating specific receptor tyrosine kinase positive signaling pathways, such as Ras-MAPK and PI3K-Akt cascades. Once activated, neurotrophic factor receptors ...
c-Jun regulates phosphoinositide-dependent kinase 1 transcription: implication for Akt and protein kinase C activities and melanoma tumorigenesis
(American Society For Biochemistry And Molecular Biology, 2010-01-08)
utations in N-RAS and B-RAF, which commonly occur in melanomas, result in constitutive activation of the mitogen-activated protein kinase (MAPK)/extracellular signal-regulated protein kinase (ERK) signaling. Active ERK ...
Modulação das vias de sinalização intracelulares de células imortalizadas do túbulo proximal de rato submetidas a altas concentrações de frutose
(Universidade Federal de São Paulo (UNIFESP), 2017-11-30)
For decades, technological advances and improvement in financial conditions associated with a sedentary lifestyle and an increase in the daily caloric intake of the world population, mainly western, resulted in changes in ...
Modelagem do fenótipo de diabetes em Nauphoeta cinerea usando estreptozotocina: Foco no metabolismo da glicose no cérebro
(Universidade Federal de Santa MariaBrasilBioquímicaUFSMPrograma de Pós-Graduação em Ciências Biológicas: Bioquímica ToxicológicaCentro de Ciências Naturais e Exatas, 2021-05-16)
The brain is highly dependent on adequate glucose catabolism, but changes in brain glucose transport are well documented in hyperglycemic conditions. Recent evidence of “hyperglycemic memory" further suggests that chronic ...