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Solar uv radiation-induced dna bipyrimidine photoproducts: Formation and mechanistic insights
(Springer Verlag, 2015)
UMP kinase from Mycobacterium tuberculosis: Mode of action and allosteric interactions, and their likely role in pyrimidine metabolism regulation
(2011-01-15)
The pyrH-encoded uridine 5′-monophosphate kinase (UMPK) is involved in both de novo and salvage synthesis of DNA and RNA precursors. Here we describe Mycobacterium tuberculosis UMPK (MtUMPK) cloning and expression in ...
Canonical WNT signaling regulates development of bovine embryos to the blastocyst stage
(2013-03-01)
Objectives were to evaluate the role of canonical WNT signaling in development of the preimplantation embryo. Signaling was activated with 2-Amino-4-(3,4-(methylenedioxy)benzylamino)-6-(3-methoxyphenyl)pyrimidine (AMBMP) ...
Canonical WNT signaling regulates development of bovine embryos to the blastocyst stage
(2013-03-01)
Objectives were to evaluate the role of canonical WNT signaling in development of the preimplantation embryo. Signaling was activated with 2-Amino-4-(3,4-(methylenedioxy)benzylamino)-6-(3-methoxyphenyl)pyrimidine (AMBMP) ...
UMP kinase from Mycobacterium tuberculosis: Mode of action and allosteric interactions, and their likely role in pyrimidine metabolism regulation
(2011-01-15)
The pyrH-encoded uridine 5′-monophosphate kinase (UMPK) is involved in both de novo and salvage synthesis of DNA and RNA precursors. Here we describe Mycobacterium tuberculosis UMPK (MtUMPK) cloning and expression in ...
Evaluating the pyrimidine metabolism in the plant pathogen Phytophthora infestans as a target to control the late blight disease
(UniandesDoctorado en Ciencias - BiologíaFacultad de CienciasDepartamento de Biología, 2016)
This project studied pyrimidine metabolism in Phytophthora infestans, not only because it has been positioned as a model organism to study oomycetes, it can be grown m vitro and in vivo in potatoes and tomatoes (and some ...
Lapachol, a compound targeting pyrimidine metabolism, ameliorates experimental autoimmune arthritis
(BioMed Central, 2017)
Abstract
Background
The inhibition of pyrimidine biosynthesis by blocking the dihydroorotate dehydrogenase (DHODH) activity, the prime target of leflunomide (LEF), has been ...