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Mastering organismal aging through the endoplasmic reticulum proteostasis network
(Wiley, 2020)
The aging process is characterized by a progressive decline in the function of most tissues, representing the main risk factor in the development of a variety of human diseases. Studies in multiple animal models have ...
Commentary: XBP-1 Is a Cell-Nonautonomous Regulator of Stress Resistance and Longevity
(Frontiers Media, 2016)
Global and local mechanisms sustain axonal proteostasis of transmembrane proteins
(Blackwell Munksgaard, 2017)
© 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd The control of neuronal protein homeostasis or cursive is tightly regulated both spatially and temporally, assuring accurate and integrated responses to ...
ER proteostasis addiction in cancer biology: Novel concepts
(Academic Press, 2015)
© 2015 Elsevier Ltd. Endoplasmic reticulum (ER) stress is generated by various physiological and pathological conditions that induce an accumulation of misfolded proteins in its lumen. ER stress activates the unfolded ...
ER Proteostasis Control of Neuronal Physiology and Synaptic Function
(Elsevier Ltd, 2018)
© 2018 Elsevier Ltd Neuronal proteostasis is maintained by the dynamic integration of different processes that regulate the synthesis, folding, quality control, and localization of proteins. The endoplasmic reticulum (ER) ...
(off) Targeting UPR signaling: the race toward intervening ER proteostasis
(Taylor & Francis, 2018)
(off)Targeting UPR signaling: the race toward intervening ER proteostasis
(Taylor and Francis Ltd, 2018)
Endoplasmic reticulum proteostasis impairment in aging
(2017)
Perturbed neuronal proteostasis is a salient feature shared by both aging and protein misfolding disorders. The proteostasis network controls the health of the proteome by integrating pathways involved in protein synthesis, ...
Bursting the unfolded protein response accelerates axonal regeneration
(Medknow Publications, 2016)
The ER proteostasis network in ALS: Determining the differential motoneuron vulnerability
(Elsevier Ireland Ltd, 2017)
© 2016 Elsevier Ireland Ltd Amyotrophic lateral sclerosis (ALS) is a fatal late-onset neurodegenerative disease characterized by the selective loss of motoneurons. The mechanisms underlying neuronal degeneration in ALS are ...