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The pros and cons of targeting Protein Kinase C (PKC) in the management of cancer patients
(Bentham Science Publishers, 2011-11)
In the last years, PKC has become an attractive target for the treatment of cancer patients given its widely described role in carcinogenesis and tumor promotion. Despite the extensive research conducted on these phorbol ...
Identification of epsilon PKC Targets During Cardiac Ischemic Injury
(JAPANESE CIRCULATION SOCKYOTO, 2012)
Background: Epsilon-protein kinase C (epsilon PKC) protects the heart from ischemic injury. However, the mechanism(s) of epsilon PKC cardioprotection is still unclear. Identification of the epsilon PKC targets may aid in ...
Requirements for PKC-augmented JNK activation by MKK4/7
(Elsevier, 2008)
The c-Jun N-terminal kinases (JNKs) are activated in response to stress, DNA damage, and cytokines by MKK4 and MKK7. We recently demonstrated that PKC can augment the degree of JNK activation by phosphorylating JNK, which ...
SmPKC1, a new protein kinase C identified in the platyhelminth parasiteSchistosoma mansoni
(Academic Press, 2013)
Contribution of individual PKC isoforms to breast cancer progression
(Wiley, 2012-01)
The protein kinase C (PKC) family of serine/threonine kinases has been intensively studied in cancer since their discovery as major receptors for the tumor-promoting phorbol esters. The contribution of each individual PKC ...
PKC beta II inhibition attenuates myocardial infarction induced heart failure and is associated with a reduction of fibrosis and pro-inflammatory responses
(WILEY-BLACKWELL, 2011)
Protein kinase C beta II (PKC beta II) levels increase in the myocardium of patients with end-stage heart failure (HF). Also targeted overexpression of PKC beta II in the myocardium of mice leads to dilated cardiomyopathy ...