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Trypanosoma cruzi evades the complement system as an efficient strategy to survive in the Mammalian host: the specific roles of host/parasite molecules and Trypanosoma cruzi Calreticulin
(Frontiers media SA, 2017)
American Trypanosomiasis is an important neglected reemerging tropical parasitism,
infecting about 8 million people worldwide. Its agent, Trypanosoma cruzi, exhibits
multiple mechanisms to evade the host immune response ...
Modulators of complement activation: a patent review (2008 - 2013)
(Informa Healthcare, 2014-03)
Introduction: The architecture of the complement system has evolved during the last 600 – 700 million years to become an amazingly efficient and highly versatile alerting and cell killing device. Under physiological ...
The role of apoptosis proteins and complement components in the etiopathogenesis of systemic lupus erythematosus
(Faculdade de Medicina / USP, 2010)
Systemic lupus erythematosus is a prototypical autoimmune disease characterized by the deregulation of T and B cells, tissue infiltration by mononuclear cells, tissue damage and the production of autoantibodies. There is ...
Expression of the crucifer-infecting TMV-Cg movement protein in tobacco plants complements in trans a TMV-U1 trafficking-deficient mutant
(Sociedad de Biología de Chile, 2006)
Anticomplementary Activity of Horse IgG and F(ab’)2 Antivenoms
(2014)
Envenomation by poisonous animals is a neglected condition according to the World Health Organization (WHO). Antivenoms are included in the WHO Essential Medicines List. It has been assumed that immunoglobulin G (IgG) ...
Extracellular Trypanosoma cruzi calreticulin in the host-parasite interplay
(Elsevier, 2011-03)
Calreticulin (CRT) from vertebrates is a calcium-binding protein present mainly in the endoplasmic reticulum (ER). There, it directs the conformation of proteins and controls calcium levels. This review will focus on several ...
On the three-finger protein domain fold and CD59-like proteins in Schistosoma mansoni
(Public Library of ScienceSan Francisco, 2013-10-24)
Background: It is believed that schistosomes evade complement-mediated killing by expressing regulatory proteins on their surface. Recently, six homologues of human CD59, an important inhibitor of the complement system ...
Cloning and expression of a functionally active truncated N-glycosylated KSHVORF4/KCP/Kaposica in the methylotrophic yeast Pichia pastoris
(New York Acad Sciences, 2005-01-01)
Kaposi's sarcoma herpesvirus (KSHV) is a typical DNA virus that is associated with a number of proliferative diseases including Kaposi's sarcoma. the KSHV open reading frame (ORF) 4 encodes a complement regulatory protein ...