The specific recognition of DNA binding sites by transcription factors (TFs) is key for the regulation of gene expression. However, most of TFs target short DNA sites and higher specificity is normally achieved by the ...

Protein-DNA binding specificity is currently represented using two-dimensional DNA sequence logos. These logos contain the frequency of occurrence of the four nucleotides at each position of the binding site. Based on this ...

The energetic contributions of individual DNA-contacting side chains to specific DNA recognition in the human papillomavirus 16 E2C-DNA complex is small (less than 1.0 kcal mol-1), independent of the physical and chemical ...

Bending of the seemingly stiff DNA double helix is a fundamental physical process for any living organism. Specialized proteins recognize DNA inducing and stabilizing sharp curvatures of the double helix. However, experimental ...

Protein recognition of DNA sites is a primary event for gene function. Its ultimate mechanistic understanding requires an integrated structural, dynamic, kinetic, and thermodynamic dissection that is currently limited ...

Heat shock proteins (HSPs), also known as molecular chaperones, participate in important cellular processes, such as protein aggregation, disaggregation, folding, and unfolding. HSPs have cytoprotective functions that are ...

Anti-double-stranded DNA monoclonal antibodies against a viral transcriptional regulatory site are capable of discriminating single-base replacements with affinities of 1 x 10(-9) M, which were optimized for the length of ...