Buscar
Mostrando ítems 1-10 de 95
Small-Molecule-Induced Soluble Oligomers of α-Synuclein with Helical Structure
(Wiley VCH Verlag, 2017-09)
Accumulation of α-synuclein (αSyn) aggregates constitutes the hallmark of synucleinopathies including Parkinson's disease. However, many steps from the innocuous, monomeric αSyn toward misfolded oligomers and fibrillar ...
An ERcentric view of Parkinson's disease
(2013)
Parkinson's disease (PD) is the second most common neurodegenerative disease and is characterized by the selective loss of dopaminergic neurons of the substantia nigra pars compacta and the accumulation of intracellular ...
Structural Insights into Amyloid Oligomers of the Parkinson Disease-related Protein α-Synuclein
(American Society for Biochemistry and Molecular Biology, 2014-09)
The presence of intraneuronal deposits mainly formed by amyloid fibrils of the presynaptic protein α-synuclein (AS) is a hallmark of Parkinson disease. Currently, neurotoxicity is attributed to prefibrillar oligomeric ...
Structural disorder of monomeric α-synuclein persists in mammalian cells
(Nature Publishing Group, 2016-02)
Intracellular aggregation of the human amyloid protein α-synuclein is causally linked to Parkinson's disease. While the isolated protein is intrinsically disordered, its native structure in mammalian cells is not known. ...
A new model to study cell-to-cell transfer of αSynuclein in vivo
(Elsevier B.V., 2018)
© 2018 Elsevier Inc. Parkinson's disease (PD) compromises motor control due to the loss of dopaminergic neurons in the substantia nigra pars compacta. At the histopathological level, PD is characterized by the accumulation ...
Drp-1 dependent mitochondrial fragmentation and protective autophagy in dopaminergic SH-SY5Y cells overexpressing alpha-synuclein
(Academic Press Inc Elsevier Science, 2018-04)
Parkinson's disease is a neurodegenerative movement disorder caused by the loss of dopaminergic neurons from substantia nigra. It is characterized by the accumulation of aggregated α-synuclein as the major component of the ...
Effects of alpha-synuclein post-translational modifications on metal binding
(Wiley Blackwell Publishing, Inc, 2019-05-16)
Parkinson’s disease is the second most common neurodegenerative disorder worldwide. Neurodegeneration in this pathology is characterized by the loss of dopaminergic neurons in the substantia nigra, coupled with cytoplasmic ...
Conformational ensemble of human α-synuclein physiological form predicted by molecular simulations
(Royal Society of Chemistry, 2016-01)
We perform here enhanced sampling simulations of N-terminally acetylated human α-synuclein, an intrinsically disordered protein involved in Parkinson's disease. The calculations, consistent with experiments, suggest that ...