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Cellular Responses to Proteasome Inhibition: Molecular Mechanisms and Beyond
(Facultad de Medicina y CienciaCentro de Biología Celular y Biomedicina CEBICEM, 2019)
Proteasome inhibitors have been actively tested as potential anticancer drugs and in the treatment of inflammatory and autoimmune diseases. Unfortunately, cells adapt to survive in the presence of proteasome inhibitors ...
Proteasome Inhibition Represses Unfolded Protein Response and Nox4, Sensitizing Vascular Cells to Endoplasmic Reticulum Stress-Induced Death
(PUBLIC LIBRARY SCIENCE, 2011)
Background: Endoplasmic reticulum (ER) stress has pathophysiological relevance in vascular diseases and merges with proteasome function. Proteasome inhibition induces cell stress and may have therapeutic implications. ...
Inhibition of proteasome activity blocks Trypanosoma cruzi growth and metacyclogenesis
(Springer Verlag (Germany), 2019)
Activation of Chymotrypsin-Like Activity of the Proteasome during Ischemia Induces Myocardial Dysfunction and Death
(2016)
Inhibitors of the ubiquitin-proteasome system improve hemodynamic parameters and decrease the infarct size after ischemia reperfusion. The molecular basis of this protection is not fully understood since most available ...
Age-dependent protein modifications and declining proteasome activity in the human lens
(ELSEVIER SCIENCE INC, 2004)
The proteasome is known to be the main enzymatic complex responsible for the intracellular degradation of altered proteins, and the age-related accumulation of modified lens proteins is associated to the formation of ...
Peptidomic Analysis of HEK293T Cells: Effect of the Proteasome Inhibitor Epoxomicin on Intracellular Peptides
(AMER CHEMICAL SOCWASHINGTON, 2012)
Peptides derived from cytosolic, mitochondrial, and nuclear proteins have been detected in extracts of animal tissues and cell lines. To test whether the proteasome is involved in their formation, HEK293T cells were treated ...
Piperlongumine and some of its analogs inhibit selectively the human immunoproteasome over the constitutive proteasome
(2018-02-12)
The natural small molecule piperlongumine A is toxic selectively to cancer cells in vitro and in vivo. This toxicity has been correlated with cancer cell ROS, DNA damage and apoptotic cell death increases. We demonstrate ...
Analysis of proteasomal proteolysis during the in vitro metacyclogenesis of Trypanosoma cruzi
(Public Library of Science, 2020)
Cellular responses to proteasome inhibition : Molecular mechanisms and beyond
(2019-07-02)
Proteasome inhibitors have been actively tested as potential anticancer drugs and in the treatment of inflammatory and autoimmune diseases. Unfortunately, cells adapt to survive in the presence of proteasome inhibitors ...