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Impaired proplatelet formation in immune thrombocytopenia: a novel mechanism contributing to decreased platelet count
(Wiley, 2014-06)
The pathophysiological mechanisms contributing to the decreased platelet count in immune thrombocytopenia (ITP) are not entirely understood. Here, we investigated the key step of proplatelet formation (PPF) by studying the ...
Anagrelide platelet-lowering effect is due to inhibition of both megakaryocyte maturation and proplatelet formation: Insight into potential mechanisms
(Wiley Blackwell Publishing, Inc, 2015-04)
Background and Objectives: Anagrelide represents a treatment option for essential thrombocythemia patients. It lowers platelet counts through inhibition of megakaryocyte maturation and polyploidization, although the basis ...
Abnormal proplatelet formation and emperipolesis in cultured human megakaryocytes from gray platelet syndrome patients
(Nature Publishing Group, 2016-03)
The Gray Platelet Syndrome (GPS) is a rare inherited bleeding disorder characterized by deficiency ofplatelet α-granules, macrothrombocytopenia and marrow fibrosis. The autosomal recessive form ofGPS is linked to loss of ...
Activation of toll‐like receptors 2 and 4 on CD 34 + cells increases human megakaryo/thrombopoiesis induced by thrombopoietin
(Wiley Blackwell Publishing, Inc, 2019-09)
Background: Platelet Toll‐like receptor (TLR)2/4 are key players in amplifying the host immune response; however, their role in human megakaryo/thrombopoiesis has not yet been defined. Objectives: We evaluated whether ...
Paracrine regulation of megakaryo/thrombopoiesis by macrophages
(Elsevier Science Inc, 2011-07)
Objective: Megakaryo/thrombopoiesis is a complex process regulated by multiple signals provided by the bone marrow microenvironment. Because macrophages are relevant components of the bone marrow stroma and their activation ...
Differential expression of SDF-1 receptor CXCR4 in molecularly defined forms of inherited thrombocytopenias
(Taylor & Francis Ltd, 2016-12)
The SDF-1-CXCR4 axis plays an essential role in the regulation of platelet production, by directing megakaryocyte (MK) migration toward the vascular niche, thus allowing terminal maturation and proplatelet formation, and ...
Autoantibodies in immune thrombocytopenia affect the physiological interaction between megakaryocytes and bone marrow extracellular matrix proteins
(Wiley Blackwell Publishing, Inc, 2017-10)
Immune thrombocytopenia (ITP) is characterized by itsheterogeneity among patients with regard to both clinicalfeatures and response to treatment. Although there isstill much to investigate, this heterogeneity could be ...
Pathogenic mechanisms contributing to thrombocytopenia in patients with systemic lupus erythematosus
(Taylor & Francis Ltd, 2021-11)
Systemic lupus erythematosus (SLE) is an autoimmune condition developing thrombocytopenia in about 10?15% of cases, however, mechanisms leading to low platelet count were not deeply investigated in this illness. Here we ...
Production of functional platelet-like particles by the megakaryoblastic DAMI cell line provides a model for platelet biogenesis
(Taylor & Francis, 2010-12)
The aim of this study was to evaluate cell maturation and the platelet production capacity of the megakaryoblastic DAMI cell line, to characterize platelet-like particles produced and to investigate the mechanisms involved ...